Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes

Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes

Information on bronchoalveolar lavage (BAL) in patients with COVID-19 is limited, and clinical correlation has not been reported. This study investigated the key features of BAL fluids from COVID-19 patients and assessed their clinical significance. A total of 320 BAL samples from 83 COVID-19 patien...

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Veröffentlicht in:Human pathology 2021-07, Vol.113, p.92-103
Hauptverfasser: Gelarden, Ian, Nguyen, Jessica, Gao, Juehua, Chen, Qing, Morales-Nebreda, Luisa, Wunderink, Richard, Li, Lin, Chmiel, Joan S., Hrisinko, MaryAnn, Marszalek, Laura, Momnani, Sumaiya, Patel, Pinal, Sumugod, Ricardo, Chao, Qi, Jennings, Lawrence J., Zembower, Teresa R., Ji, Peng, Chen, Yi-Hua
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Atypical lymphocyte
Bronchoalveolar lavage
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Clinical outcome
Coronaviruses
COVID-19
COVID-19 - immunology
Female
Humans
Lung - immunology
Lymphocytes
Male
Middle Aged
Mortality
Original Contribution
SARS-CoV-2
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Zusammenfassung:Information on bronchoalveolar lavage (BAL) in patients with COVID-19 is limited, and clinical correlation has not been reported. This study investigated the key features of BAL fluids from COVID-19 patients and assessed their clinical significance. A total of 320 BAL samples from 83 COVID-19 patients and 70 non-COVID-19 patients (27 patients with other respiratory viral infections) were evaluated, including cell count/differential, morphology, flow cytometric immunophenotyping, and immunohistochemistry. The findings were correlated with clinical outcomes. Compared to non-COVID-19 patients, BAL from COVID-19 patients was characterized by significant lymphocytosis (p 
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2021.04.010