Age-associated proinflammatory elastic fiber remodeling in large arteries
•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, stru...
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Veröffentlicht in: | Mechanisms of ageing and development 2021-06, Vol.196, p.111490-111490, Article 111490 |
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description | •Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases.
Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age. |
doi_str_mv | 10.1016/j.mad.2021.111490 |
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Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.</description><identifier>ISSN: 0047-6374</identifier><identifier>ISSN: 1872-6216</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/j.mad.2021.111490</identifier><identifier>PMID: 33839189</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aging ; Aging - physiology ; Arteries - pathology ; Arteries - physiopathology ; Elastic fibers ; Elastic Tissue - immunology ; Elastic Tissue - pathology ; Elastic Tissue - physiopathology ; Heart Disease Risk Factors ; Humans ; Inflammation - pathology ; Inflammation - physiopathology ; Large artery ; Proinflammation ; Vascular Remodeling - immunology</subject><ispartof>Mechanisms of ageing and development, 2021-06, Vol.196, p.111490-111490, Article 111490</ispartof><rights>2021</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</citedby><cites>FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</cites><orcidid>0000-0001-6412-369X ; 0000-0002-3405-4264</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mad.2021.111490$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33839189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Soo Hyuk</creatorcontrib><creatorcontrib>Monticone, Robert E.</creatorcontrib><creatorcontrib>McGraw, Kimberly R.</creatorcontrib><creatorcontrib>Wang, Mingyi</creatorcontrib><title>Age-associated proinflammatory elastic fiber remodeling in large arteries</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases.
Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Arteries - pathology</subject><subject>Arteries - physiopathology</subject><subject>Elastic fibers</subject><subject>Elastic Tissue - immunology</subject><subject>Elastic Tissue - pathology</subject><subject>Elastic Tissue - physiopathology</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Inflammation - physiopathology</subject><subject>Large artery</subject><subject>Proinflammation</subject><subject>Vascular Remodeling - immunology</subject><issn>0047-6374</issn><issn>1872-6216</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LxDAQhoMo7vrxA7xIj166ZpI0bREEET8WBC96DtN0umZpmzXpLvjvrawuevE0h3nmnZn3ZewM-Aw46MvlrMN6JriAGQCoku-xKRS5SLUAvc-mnKs81TJXE3YU45JzDkroQzaRspAlFOWUzW8WlGKM3jocqE5Wwbu-abHrcPDhI6EW4-Bs0riKQhKo8zW1rl8krk9aDAtKMAwUHMUTdtBgG-n0ux6z1_u7l9vH9On5YX5785RalcGQykbKSiCSllaAJRS8zBtdAVR1nTe5rhSJqrRCYClQ80xV2fiOzYpcaV2QPGbXW93VuuqottQPAVuzCq7D8GE8OvO307s3s_AbU0CmciFHgYtvgeDf1xQH07loqW2xJ7-ORmQwWqNlyUcUtqgNPsZAzW4NcPMVgVmaMQLzFYHZRjDOnP--bzfx4_kIXG0BGl3aOAomWke9pdoFsoOpvftH_hMo8pgs</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Kim, Soo Hyuk</creator><creator>Monticone, Robert E.</creator><creator>McGraw, Kimberly R.</creator><creator>Wang, Mingyi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6412-369X</orcidid><orcidid>https://orcid.org/0000-0002-3405-4264</orcidid></search><sort><creationdate>20210601</creationdate><title>Age-associated proinflammatory elastic fiber remodeling in large arteries</title><author>Kim, Soo Hyuk ; Monticone, Robert E. ; McGraw, Kimberly R. ; Wang, Mingyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Arteries - pathology</topic><topic>Arteries - physiopathology</topic><topic>Elastic fibers</topic><topic>Elastic Tissue - immunology</topic><topic>Elastic Tissue - pathology</topic><topic>Elastic Tissue - physiopathology</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Inflammation - physiopathology</topic><topic>Large artery</topic><topic>Proinflammation</topic><topic>Vascular Remodeling - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Soo Hyuk</creatorcontrib><creatorcontrib>Monticone, Robert E.</creatorcontrib><creatorcontrib>McGraw, Kimberly R.</creatorcontrib><creatorcontrib>Wang, Mingyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Soo Hyuk</au><au>Monticone, Robert E.</au><au>McGraw, Kimberly R.</au><au>Wang, Mingyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-associated proinflammatory elastic fiber remodeling in large arteries</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>196</volume><spage>111490</spage><epage>111490</epage><pages>111490-111490</pages><artnum>111490</artnum><issn>0047-6374</issn><issn>1872-6216</issn><eissn>1872-6216</eissn><abstract>•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases.
Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33839189</pmid><doi>10.1016/j.mad.2021.111490</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6412-369X</orcidid><orcidid>https://orcid.org/0000-0002-3405-4264</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aging Aging - physiology Arteries - pathology Arteries - physiopathology Elastic fibers Elastic Tissue - immunology Elastic Tissue - pathology Elastic Tissue - physiopathology Heart Disease Risk Factors Humans Inflammation - pathology Inflammation - physiopathology Large artery Proinflammation Vascular Remodeling - immunology |
title | Age-associated proinflammatory elastic fiber remodeling in large arteries |
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