Age-associated proinflammatory elastic fiber remodeling in large arteries

•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, stru...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mechanisms of ageing and development 2021-06, Vol.196, p.111490-111490, Article 111490
Hauptverfasser: Kim, Soo Hyuk, Monticone, Robert E., McGraw, Kimberly R., Wang, Mingyi
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 111490
container_issue
container_start_page 111490
container_title Mechanisms of ageing and development
container_volume 196
creator Kim, Soo Hyuk
Monticone, Robert E.
McGraw, Kimberly R.
Wang, Mingyi
description •Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases. Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.
doi_str_mv 10.1016/j.mad.2021.111490
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8154723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0047637421000622</els_id><sourcerecordid>2511896390</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</originalsourceid><addsrcrecordid>eNp9kU1LxDAQhoMo7vrxA7xIj166ZpI0bREEET8WBC96DtN0umZpmzXpLvjvrawuevE0h3nmnZn3ZewM-Aw46MvlrMN6JriAGQCoku-xKRS5SLUAvc-mnKs81TJXE3YU45JzDkroQzaRspAlFOWUzW8WlGKM3jocqE5Wwbu-abHrcPDhI6EW4-Bs0riKQhKo8zW1rl8krk9aDAtKMAwUHMUTdtBgG-n0ux6z1_u7l9vH9On5YX5785RalcGQykbKSiCSllaAJRS8zBtdAVR1nTe5rhSJqrRCYClQ80xV2fiOzYpcaV2QPGbXW93VuuqottQPAVuzCq7D8GE8OvO307s3s_AbU0CmciFHgYtvgeDf1xQH07loqW2xJ7-ORmQwWqNlyUcUtqgNPsZAzW4NcPMVgVmaMQLzFYHZRjDOnP--bzfx4_kIXG0BGl3aOAomWke9pdoFsoOpvftH_hMo8pgs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2511896390</pqid></control><display><type>article</type><title>Age-associated proinflammatory elastic fiber remodeling in large arteries</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kim, Soo Hyuk ; Monticone, Robert E. ; McGraw, Kimberly R. ; Wang, Mingyi</creator><creatorcontrib>Kim, Soo Hyuk ; Monticone, Robert E. ; McGraw, Kimberly R. ; Wang, Mingyi</creatorcontrib><description>•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases. Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.</description><identifier>ISSN: 0047-6374</identifier><identifier>ISSN: 1872-6216</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/j.mad.2021.111490</identifier><identifier>PMID: 33839189</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aging ; Aging - physiology ; Arteries - pathology ; Arteries - physiopathology ; Elastic fibers ; Elastic Tissue - immunology ; Elastic Tissue - pathology ; Elastic Tissue - physiopathology ; Heart Disease Risk Factors ; Humans ; Inflammation - pathology ; Inflammation - physiopathology ; Large artery ; Proinflammation ; Vascular Remodeling - immunology</subject><ispartof>Mechanisms of ageing and development, 2021-06, Vol.196, p.111490-111490, Article 111490</ispartof><rights>2021</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</citedby><cites>FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</cites><orcidid>0000-0001-6412-369X ; 0000-0002-3405-4264</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mad.2021.111490$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33839189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Soo Hyuk</creatorcontrib><creatorcontrib>Monticone, Robert E.</creatorcontrib><creatorcontrib>McGraw, Kimberly R.</creatorcontrib><creatorcontrib>Wang, Mingyi</creatorcontrib><title>Age-associated proinflammatory elastic fiber remodeling in large arteries</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases. Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Arteries - pathology</subject><subject>Arteries - physiopathology</subject><subject>Elastic fibers</subject><subject>Elastic Tissue - immunology</subject><subject>Elastic Tissue - pathology</subject><subject>Elastic Tissue - physiopathology</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Inflammation - physiopathology</subject><subject>Large artery</subject><subject>Proinflammation</subject><subject>Vascular Remodeling - immunology</subject><issn>0047-6374</issn><issn>1872-6216</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LxDAQhoMo7vrxA7xIj166ZpI0bREEET8WBC96DtN0umZpmzXpLvjvrawuevE0h3nmnZn3ZewM-Aw46MvlrMN6JriAGQCoku-xKRS5SLUAvc-mnKs81TJXE3YU45JzDkroQzaRspAlFOWUzW8WlGKM3jocqE5Wwbu-abHrcPDhI6EW4-Bs0riKQhKo8zW1rl8krk9aDAtKMAwUHMUTdtBgG-n0ux6z1_u7l9vH9On5YX5785RalcGQykbKSiCSllaAJRS8zBtdAVR1nTe5rhSJqrRCYClQ80xV2fiOzYpcaV2QPGbXW93VuuqottQPAVuzCq7D8GE8OvO307s3s_AbU0CmciFHgYtvgeDf1xQH07loqW2xJ7-ORmQwWqNlyUcUtqgNPsZAzW4NcPMVgVmaMQLzFYHZRjDOnP--bzfx4_kIXG0BGl3aOAomWke9pdoFsoOpvftH_hMo8pgs</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Kim, Soo Hyuk</creator><creator>Monticone, Robert E.</creator><creator>McGraw, Kimberly R.</creator><creator>Wang, Mingyi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6412-369X</orcidid><orcidid>https://orcid.org/0000-0002-3405-4264</orcidid></search><sort><creationdate>20210601</creationdate><title>Age-associated proinflammatory elastic fiber remodeling in large arteries</title><author>Kim, Soo Hyuk ; Monticone, Robert E. ; McGraw, Kimberly R. ; Wang, Mingyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-3f33b2aae63c21cea2097f6b11bdd7f76b4e2b9c22a92a6054b5621c5874668e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Arteries - pathology</topic><topic>Arteries - physiopathology</topic><topic>Elastic fibers</topic><topic>Elastic Tissue - immunology</topic><topic>Elastic Tissue - pathology</topic><topic>Elastic Tissue - physiopathology</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Inflammation - physiopathology</topic><topic>Large artery</topic><topic>Proinflammation</topic><topic>Vascular Remodeling - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Soo Hyuk</creatorcontrib><creatorcontrib>Monticone, Robert E.</creatorcontrib><creatorcontrib>McGraw, Kimberly R.</creatorcontrib><creatorcontrib>Wang, Mingyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Soo Hyuk</au><au>Monticone, Robert E.</au><au>McGraw, Kimberly R.</au><au>Wang, Mingyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-associated proinflammatory elastic fiber remodeling in large arteries</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>196</volume><spage>111490</spage><epage>111490</epage><pages>111490-111490</pages><artnum>111490</artnum><issn>0047-6374</issn><issn>1872-6216</issn><eissn>1872-6216</eissn><abstract>•Elastic laminae are the main components of the extracellular matrix of large arteries.•Elastic lamina remodeling is an intricate process of synthesis and degradation of the core tropoelastin protein accompanied by the assembly and disassembly with accessory proteins.•Age related morphological, structural, and functional proinflammatory remodeling within the elastic laminae has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall.•Age-associated increase in arterial elastic fiber remodeling plays an important role in the pathogenesis of large arterial diseases. Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>33839189</pmid><doi>10.1016/j.mad.2021.111490</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6412-369X</orcidid><orcidid>https://orcid.org/0000-0002-3405-4264</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0047-6374
ispartof Mechanisms of ageing and development, 2021-06, Vol.196, p.111490-111490, Article 111490
issn 0047-6374
1872-6216
1872-6216
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8154723
source MEDLINE; Elsevier ScienceDirect Journals
subjects Aging
Aging - physiology
Arteries - pathology
Arteries - physiopathology
Elastic fibers
Elastic Tissue - immunology
Elastic Tissue - pathology
Elastic Tissue - physiopathology
Heart Disease Risk Factors
Humans
Inflammation - pathology
Inflammation - physiopathology
Large artery
Proinflammation
Vascular Remodeling - immunology
title Age-associated proinflammatory elastic fiber remodeling in large arteries
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T08%3A21%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-associated%20proinflammatory%20elastic%20fiber%20remodeling%20in%20large%20arteries&rft.jtitle=Mechanisms%20of%20ageing%20and%20development&rft.au=Kim,%20Soo%20Hyuk&rft.date=2021-06-01&rft.volume=196&rft.spage=111490&rft.epage=111490&rft.pages=111490-111490&rft.artnum=111490&rft.issn=0047-6374&rft.eissn=1872-6216&rft_id=info:doi/10.1016/j.mad.2021.111490&rft_dat=%3Cproquest_pubme%3E2511896390%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2511896390&rft_id=info:pmid/33839189&rft_els_id=S0047637421000622&rfr_iscdi=true