Serial Whole-Brain N-Acetylaspartate Concentration in Healthy Young Adults

Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years...

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Veröffentlicht in:	American Journal of Neuroradiology 2007-10, Vol.28 (9), p.1650-1651
Hauptverfasser:	Rigotti, D.J, Inglese, M, Babb, J.S, Rovaris, M, Benedetti, B, Filippi, M, Grossman, R.I, Gonen, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Biological and medical sciences Brain Brain - metabolism Electrodiagnosis. Electric activity recording Female Fundamental and applied biological sciences. Psychology Humans Investigative techniques, diagnostic techniques (general aspects) Longitudinal Studies Magnetic Resonance Spectroscopy - methods Male Medical sciences Middle Aged Nervous system Personality. Affectivity Protons Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values Reproducibility of Results Sensitivity and Specificity Sexuality. Sexual behavior
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Zusammenfassung:	Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1-2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study.
ISSN:	0195-6108 1936-959X 1432-1920
DOI:	10.3174/ajnr.A0712