Converging Evidence on D-Amino Acid Oxidase–Dependent Enhancement of Hippocampal Firing Activity and Passive Avoidance Learning in Rats

Abstract Background N-methyl-D-aspartate (NMDA) receptor activation requires the binding of a co-agonist on the glycine-binding site. D-serine is the main endogenous co-agonist of NMDA receptors, and its availability significantly depends on the activity of the metabolic enzyme D-amino acid oxidase...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2021-05, Vol.24 (5), p.434-445
Hauptverfasser:	Nagy, Lili Veronika, Bali, Zsolt Kristóf, Kapus, Gábor, Pelsőczi, Péter, Farkas, Bence, Lendvai, Balázs, Lévay, György, Hernádi, István
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Brain research D-Amino-Acid Oxidase - antagonists & inhibitors Enzyme inhibitors Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Excitatory Amino Acid Agonists - pharmacology Hippocampus (Brain) Hippocampus - drug effects Hippocampus - enzymology Learning Male Memory Disorders - drug therapy Memory Disorders - enzymology Methyl aspartate N-Methylaspartate - pharmacology Neural circuitry Nootropic Agents - administration & dosage Nootropic Agents - pharmacology Oxidases Physiological aspects Psychological aspects Pyramidal Cells - drug effects Pyridinium Compounds - administration & dosage Pyridinium Compounds - pharmacology Rats Rats, Wistar Regular s
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