On Iron Metabolism and Its Regulation

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by macrophages in the spleen, liver and bone marrow. Dietary iron is taken up by the divalent metal transporter 1 (DMT...

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Veröffentlicht in:International journal of molecular sciences 2021-04, Vol.22 (9), p.4591
Hauptverfasser: Vogt, Anne-Cathrine S, Arsiwala, Tasneem, Mohsen, Mona, Vogel, Monique, Manolova, Vania, Bachmann, Martin F
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Sprache:eng
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Zusammenfassung:Iron is a critical metal for several vital biological processes. Most of the body's iron is bound to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by macrophages in the spleen, liver and bone marrow. Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1). While most of the physiologically active iron is bound hemoglobin, the major storage of most iron occurs in the liver in a ferritin-bound fashion. In response to an increased iron load, hepatocytes secrete the peptide hormone hepcidin, which binds to and induces internalization and degradation of the iron transporter FPN, thus controlling the amount of iron released from the cells into the blood. This review summarizes the key mechanisms and players involved in cellular and systemic iron regulation.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22094591