LRP1B mutation is associated with tumor HPV status and promotes poor disease outcomes with a higher mutation count in HPV-related cervical carcinoma and head & neck squamous cell carcinoma

Human papillomavirus (HPV) infection and gene mutations were reputed as key factors in cervical carcinoma (CC) and head and neck squamous cell carcinoma (HNSCC). However, the associations of HPV status and gene mutations remain to be determined. This study aims to identify molecular patterns of mutation and HPV status via rewiring tumor samples of HNSCC (n=1478) and CC (n=178) from the TCGA dataset. Here, we found that mutation was associated with HPV status in CC ( =0.040) and HNSCC ( =0.044), especially in HPV 16 integrated CC ( =0.036). Cancer survival analysis demonstrated that samples with mutation showed poor disease outcomes in CC ( =0.013) and HNSCC ( =0.0124). In addition, the expression status of was more favorable for prediction than or in CC and HNSCC. Mutation clustering analysis showed that samples with mutation showed higher mutation count in CC ( =1.76e-67) and HNSCC (