Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin
Background The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2). Methods Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing facto...
Gespeichert in:
| Veröffentlicht in: | Pediatric research 2021-04, Vol.89 (5), p.1208-1215 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1215 |
|---|---|
| container_issue | 5 |
| container_start_page | 1208 |
| container_title | Pediatric research |
| container_volume | 89 |
| creator | Visscher, Marty O. Carr, Andrew N. Winget, Jason Huggins, Thomas Bascom, Charles C. Isfort, Robert Lammers, Karen Narendran, Vivek |
| description | Background
The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).
Methods
Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were: |
| doi_str_mv | 10.1038/s41390-020-1035-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8119241</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2526475147</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-1649c0fc9c0927abf1969fdde25d5bd9126e3ee01e368d3b37ad06ccf7ca9d003</originalsourceid><addsrcrecordid>eNp1UcuOFCEUJUbjtK0f4MZU4sZNKZdHVbEx0YmvZBI3uiYUXEZmqqEFapL-e2l7HB-JG-Byzzlw7iHkKdCXQPn0qgjgivaU0b7Vsj_cIxuQvN0IMd4nG0o59Fyp6Yw8KuWKUhByEg_JGWdSqQFgQ9zbkHYmX2MuXfJdxBRNNUtXrkPsZpNzwNwZZ_bV1JBil_EGj-11LtXEGtrZBe8xY7RYOpt2e5PRdTU11rrUn0KPyQNvloJPbvct-fr-3Zfzj_3F5w-fzt9c9FaMtPYwCGWpt21RbDSzBzUo7xwy6eTsFLABOSIF5MPk-MxH4-hgrR-tUa6Z3ZLXJ939Ou_QWYw1m0Xvc2gWDzqZoP_uxPBNX6YbPQEo1oa5JS9uBXL6vmKpeheKxWUxbTBr0Q2j6DQKYA36_B_oVVpzbPY0k2wQowQxNhScUDanUjL6u88A1ccM9SlD3TI81lIfGufZny7uGL9CawB2ApTWipeYfz_9f9UfbBmqiA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2526475147</pqid></control><display><type>article</type><title>Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin</title><source>MEDLINE</source><source>SpringerLink Journals (MCLS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Visscher, Marty O. ; Carr, Andrew N. ; Winget, Jason ; Huggins, Thomas ; Bascom, Charles C. ; Isfort, Robert ; Lammers, Karen ; Narendran, Vivek</creator><creatorcontrib>Visscher, Marty O. ; Carr, Andrew N. ; Winget, Jason ; Huggins, Thomas ; Bascom, Charles C. ; Isfort, Robert ; Lammers, Karen ; Narendran, Vivek</creatorcontrib><description>Background
The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).
Methods
Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were: <34 weeks (PT), 34–<37 weeks (LPT), and ≥37 weeks (FT).
Results
Forty proteins were differentially expressed in FT infant skin, 38 in LPT infant skin, and 12 in PT infant skin compared with adult skin at T1. At T2, 40 proteins were differentially expressed in FT infants, 38 in LPT infants, and 54 in PT infants compared with adults. All proteins were increased at both times, except TMG3, S100A7, and PEBP1, and decreased in PTs at T1. The proteins are involved in filaggrin processing, protease inhibition/enzyme regulation, and antimicrobial function. Eight proteins were decreased in PT skin compared with FT skin at T1. LPT and FT proteins were generally comparable at both times. Total NMF was lower in infants than adults at T1, but higher in infants at T2.
Conclusions
Neonates respond to the physiological transitions at birth by upregulating processes that drive the production of lower pH of the skin and water-binding NMF components, prevent protease activity leading to desquamation, and increase the barrier antimicrobial properties.
Impact
Neonates respond to the transitions at birth by upregulating processes that drive the production of lower pH of the skin and NMF, prevent protease activity leading to desquamation, and increase the antimicrobial properties of the barrier.
The neonatal epidermal barrier exhibits a markedly different array of protein biomarkers both shortly after birth and 2–3 months later, which are differentially expressed versus adults.
The major biomarker-functional classes included filaggrin processing, protease inhibitor/enzyme regulators, antimicrobials, keratins, lipids, and cathepsins.
The findings will guide improvement of infant skin care practices, particularly for the most premature infants with the ultimate goals mitigating nosocomial infection.</description><identifier>ISSN: 0031-3998</identifier><identifier>ISSN: 1530-0447</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-020-1035-y</identifier><identifier>PMID: 32599611</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adult ; Adults ; Aging - physiology ; Babies ; Biomarkers ; Biomarkers - metabolism ; Biophysical Phenomena ; Clinical ; Clinical Research Article ; Enzymes ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Proteins ; Proteins - metabolism ; Proteomics - methods ; Skin Absorption</subject><ispartof>Pediatric research, 2021-04, Vol.89 (5), p.1208-1215</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1649c0fc9c0927abf1969fdde25d5bd9126e3ee01e368d3b37ad06ccf7ca9d003</citedby><cites>FETCH-LOGICAL-c470t-1649c0fc9c0927abf1969fdde25d5bd9126e3ee01e368d3b37ad06ccf7ca9d003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41390-020-1035-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41390-020-1035-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32599611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Visscher, Marty O.</creatorcontrib><creatorcontrib>Carr, Andrew N.</creatorcontrib><creatorcontrib>Winget, Jason</creatorcontrib><creatorcontrib>Huggins, Thomas</creatorcontrib><creatorcontrib>Bascom, Charles C.</creatorcontrib><creatorcontrib>Isfort, Robert</creatorcontrib><creatorcontrib>Lammers, Karen</creatorcontrib><creatorcontrib>Narendran, Vivek</creatorcontrib><title>Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).
Methods
Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were: <34 weeks (PT), 34–<37 weeks (LPT), and ≥37 weeks (FT).
Results
Forty proteins were differentially expressed in FT infant skin, 38 in LPT infant skin, and 12 in PT infant skin compared with adult skin at T1. At T2, 40 proteins were differentially expressed in FT infants, 38 in LPT infants, and 54 in PT infants compared with adults. All proteins were increased at both times, except TMG3, S100A7, and PEBP1, and decreased in PTs at T1. The proteins are involved in filaggrin processing, protease inhibition/enzyme regulation, and antimicrobial function. Eight proteins were decreased in PT skin compared with FT skin at T1. LPT and FT proteins were generally comparable at both times. Total NMF was lower in infants than adults at T1, but higher in infants at T2.
Conclusions
Neonates respond to the physiological transitions at birth by upregulating processes that drive the production of lower pH of the skin and water-binding NMF components, prevent protease activity leading to desquamation, and increase the barrier antimicrobial properties.
Impact
Neonates respond to the transitions at birth by upregulating processes that drive the production of lower pH of the skin and NMF, prevent protease activity leading to desquamation, and increase the antimicrobial properties of the barrier.
The neonatal epidermal barrier exhibits a markedly different array of protein biomarkers both shortly after birth and 2–3 months later, which are differentially expressed versus adults.
The major biomarker-functional classes included filaggrin processing, protease inhibitor/enzyme regulators, antimicrobials, keratins, lipids, and cathepsins.
The findings will guide improvement of infant skin care practices, particularly for the most premature infants with the ultimate goals mitigating nosocomial infection.</description><subject>Adult</subject><subject>Adults</subject><subject>Aging - physiology</subject><subject>Babies</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biophysical Phenomena</subject><subject>Clinical</subject><subject>Clinical Research Article</subject><subject>Enzymes</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Proteins - metabolism</subject><subject>Proteomics - methods</subject><subject>Skin Absorption</subject><issn>0031-3998</issn><issn>1530-0447</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UcuOFCEUJUbjtK0f4MZU4sZNKZdHVbEx0YmvZBI3uiYUXEZmqqEFapL-e2l7HB-JG-Byzzlw7iHkKdCXQPn0qgjgivaU0b7Vsj_cIxuQvN0IMd4nG0o59Fyp6Yw8KuWKUhByEg_JGWdSqQFgQ9zbkHYmX2MuXfJdxBRNNUtXrkPsZpNzwNwZZ_bV1JBil_EGj-11LtXEGtrZBe8xY7RYOpt2e5PRdTU11rrUn0KPyQNvloJPbvct-fr-3Zfzj_3F5w-fzt9c9FaMtPYwCGWpt21RbDSzBzUo7xwy6eTsFLABOSIF5MPk-MxH4-hgrR-tUa6Z3ZLXJ939Ou_QWYw1m0Xvc2gWDzqZoP_uxPBNX6YbPQEo1oa5JS9uBXL6vmKpeheKxWUxbTBr0Q2j6DQKYA36_B_oVVpzbPY0k2wQowQxNhScUDanUjL6u88A1ccM9SlD3TI81lIfGufZny7uGL9CawB2ApTWipeYfz_9f9UfbBmqiA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Visscher, Marty O.</creator><creator>Carr, Andrew N.</creator><creator>Winget, Jason</creator><creator>Huggins, Thomas</creator><creator>Bascom, Charles C.</creator><creator>Isfort, Robert</creator><creator>Lammers, Karen</creator><creator>Narendran, Vivek</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210401</creationdate><title>Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin</title><author>Visscher, Marty O. ; Carr, Andrew N. ; Winget, Jason ; Huggins, Thomas ; Bascom, Charles C. ; Isfort, Robert ; Lammers, Karen ; Narendran, Vivek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-1649c0fc9c0927abf1969fdde25d5bd9126e3ee01e368d3b37ad06ccf7ca9d003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aging - physiology</topic><topic>Babies</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Biophysical Phenomena</topic><topic>Clinical</topic><topic>Clinical Research Article</topic><topic>Enzymes</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Proteins</topic><topic>Proteins - metabolism</topic><topic>Proteomics - methods</topic><topic>Skin Absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visscher, Marty O.</creatorcontrib><creatorcontrib>Carr, Andrew N.</creatorcontrib><creatorcontrib>Winget, Jason</creatorcontrib><creatorcontrib>Huggins, Thomas</creatorcontrib><creatorcontrib>Bascom, Charles C.</creatorcontrib><creatorcontrib>Isfort, Robert</creatorcontrib><creatorcontrib>Lammers, Karen</creatorcontrib><creatorcontrib>Narendran, Vivek</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visscher, Marty O.</au><au>Carr, Andrew N.</au><au>Winget, Jason</au><au>Huggins, Thomas</au><au>Bascom, Charles C.</au><au>Isfort, Robert</au><au>Lammers, Karen</au><au>Narendran, Vivek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>89</volume><issue>5</issue><spage>1208</spage><epage>1215</epage><pages>1208-1215</pages><issn>0031-3998</issn><issn>1530-0447</issn><eissn>1530-0447</eissn><abstract>Background
The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).
Methods
Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were: <34 weeks (PT), 34–<37 weeks (LPT), and ≥37 weeks (FT).
Results
Forty proteins were differentially expressed in FT infant skin, 38 in LPT infant skin, and 12 in PT infant skin compared with adult skin at T1. At T2, 40 proteins were differentially expressed in FT infants, 38 in LPT infants, and 54 in PT infants compared with adults. All proteins were increased at both times, except TMG3, S100A7, and PEBP1, and decreased in PTs at T1. The proteins are involved in filaggrin processing, protease inhibition/enzyme regulation, and antimicrobial function. Eight proteins were decreased in PT skin compared with FT skin at T1. LPT and FT proteins were generally comparable at both times. Total NMF was lower in infants than adults at T1, but higher in infants at T2.
Conclusions
Neonates respond to the physiological transitions at birth by upregulating processes that drive the production of lower pH of the skin and water-binding NMF components, prevent protease activity leading to desquamation, and increase the barrier antimicrobial properties.
Impact
Neonates respond to the transitions at birth by upregulating processes that drive the production of lower pH of the skin and NMF, prevent protease activity leading to desquamation, and increase the antimicrobial properties of the barrier.
The neonatal epidermal barrier exhibits a markedly different array of protein biomarkers both shortly after birth and 2–3 months later, which are differentially expressed versus adults.
The major biomarker-functional classes included filaggrin processing, protease inhibitor/enzyme regulators, antimicrobials, keratins, lipids, and cathepsins.
The findings will guide improvement of infant skin care practices, particularly for the most premature infants with the ultimate goals mitigating nosocomial infection.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>32599611</pmid><doi>10.1038/s41390-020-1035-y</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2021-04, Vol.89 (5), p.1208-1215 |
| issn | 0031-3998 1530-0447 1530-0447 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8119241 |
| source | MEDLINE; SpringerLink Journals (MCLS); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Adults Aging - physiology Babies Biomarkers Biomarkers - metabolism Biophysical Phenomena Clinical Clinical Research Article Enzymes Female Humans Infant, Newborn Infant, Premature Male Medicine Medicine & Public Health Pediatric Surgery Pediatrics Proteins Proteins - metabolism Proteomics - methods Skin Absorption |
| title | Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T05%3A42%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomarkers%20of%20neonatal%20skin%20barrier%20adaptation%20reveal%20substantial%20differences%20compared%20to%20adult%20skin&rft.jtitle=Pediatric%20research&rft.au=Visscher,%20Marty%20O.&rft.date=2021-04-01&rft.volume=89&rft.issue=5&rft.spage=1208&rft.epage=1215&rft.pages=1208-1215&rft.issn=0031-3998&rft.eissn=1530-0447&rft_id=info:doi/10.1038/s41390-020-1035-y&rft_dat=%3Cproquest_pubme%3E2526475147%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2526475147&rft_id=info:pmid/32599611&rfr_iscdi=true |