Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin

Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin

Background The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2). Methods Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing facto...

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Veröffentlicht in:Pediatric research 2021-04, Vol.89 (5), p.1208-1215
Hauptverfasser: Visscher, Marty O., Carr, Andrew N., Winget, Jason, Huggins, Thomas, Bascom, Charles C., Isfort, Robert, Lammers, Karen, Narendran, Vivek
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Adults
Aging - physiology
Babies
Biomarkers
Biomarkers - metabolism
Biophysical Phenomena
Clinical
Clinical Research Article
Enzymes
Female
Humans
Infant, Newborn
Infant, Premature
Male
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Proteins
Proteins - metabolism
Proteomics - methods
Skin Absorption
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Zusammenfassung:Background The objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2). Methods Skin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were:
ISSN:0031-3998
1530-0447
1530-0447
DOI:10.1038/s41390-020-1035-y