Vaccine Breakthrough Infections with SARS-CoV-2 Variants

Vaccine Breakthrough Infections with SARS-CoV-2 Variants

Mild Covid-19 symptoms developed in two fully vaccinated persons. Serum tests showed high titers of antibodies capable of neutralizing the wild-type strain of SARS-CoV-2 first identified in Wuhan, China, but sequencing of the virus isolates revealed novel variants. Some mutations in the receptor-bin...

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Veröffentlicht in:The New England journal of medicine 2021-06, Vol.384 (23), p.2212-2218
Hauptverfasser: Hacisuleyman, Ezgi, Hale, Caryn, Saito, Yuhki, Blachere, Nathalie E, Bergh, Marissa, Conlon, Erin G, Schaefer-Babajew, Dennis J, DaSilva, Justin, Muecksch, Frauke, Gaebler, Christian, Lifton, Richard, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D, Darnell, Robert B
Format: Artikel
Sprache:eng
Schlagworte:
2019-nCoV Vaccine mRNA-1273
Aged
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Asymptomatic
BNT162 Vaccine
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 - virology
COVID-19 Vaccines
Employees
FDA approval
Female
Genomes
Humans
Infections
Medical laboratories
Middle Aged
mRNA
Mutation
Neutralization Tests
Original
Phylogeny
Polymerase Chain Reaction
Proteins
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
SARS-CoV-2 - isolation & purification
Sequence Analysis, RNA
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - genetics
Vaccination
Vaccine efficacy
Vaccines
Viral Load
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Zusammenfassung:Mild Covid-19 symptoms developed in two fully vaccinated persons. Serum tests showed high titers of antibodies capable of neutralizing the wild-type strain of SARS-CoV-2 first identified in Wuhan, China, but sequencing of the virus isolates revealed novel variants. Some mutations in the receptor-binding domain of the spike protein were shared by the two variant strains.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2105000