A Same-Genus Screening Approach Reveals Novel Effectors and New Possibilities for Investigating Chlamydia Pathogenesis

are obligate intracellular pathogens that rely on secreted effector proteins to establish their intracellular niche. In this issue of the , Yanatori describe a screen for effectors, performed in , which identified several new proteins that are translocated during infection (Yanatori, Miura et al. 2021). More broadly, they demonstrate how new genetic approaches in can be used to characterize the virulence factors of other species.