Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis

Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis

Cardiovascular disease is the leading cause of death and disability worldwide. Effective delivery of cell-selective therapies that target atherosclerotic plaques and neointimal growth while sparing the endothelium remains the Achilles heel of percutaneous interventions. The current study utilizes sy...

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Veröffentlicht in:Molecular therapy 2021-05, Vol.29 (5), p.1744-1757
Hauptverfasser: Lockhart, John H., VanWye, Jeffrey, Banerjee, Richa, Wickline, Samuel A., Pan, Hua, Totary-Jain, Hana
Format: Artikel
Sprache:eng
Schlagworte:
atherosclerosis
cardiovascular disease
cell-selective therapy
endosomal escape
mRNA therapeutics
nanotherapy
Original
restenosis
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Zusammenfassung:Cardiovascular disease is the leading cause of death and disability worldwide. Effective delivery of cell-selective therapies that target atherosclerotic plaques and neointimal growth while sparing the endothelium remains the Achilles heel of percutaneous interventions. The current study utilizes synthetic microRNA switch therapy that self-assembles to form a compacted, nuclease-resistant nanoparticle
ISSN:1525-0016
1525-0024
DOI:10.1016/j.ymthe.2021.01.032