Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols

Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols

An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1- с ][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2021-04, Vol.57 (4), p.473-478
Hauptverfasser: Drokin, Roman A., Tiufiakov, Dmitrii V., Voinkov, Egor K., Slepukhin, Pavel A., Ulomsky, Evgeny N., Esaulkova, Yana L., Volobueva, Alexandrina S., Lantseva, Kristina S., Misyurina, Mariya A., Zarubaev, Vladimir V., Rusinov, Vladimir L.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Influenza
Ketones
Laninamivir
Methods
Organic Chemistry
Pharmacy
Substitution reactions
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Zusammenfassung:An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1- с ][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-021-02926-2