Residual immune activation in HIV-Infected individuals expands monocytic-myeloid derived suppressor cells
•M-MDSC persist in HIV (+) individuals despite prolonged treatment with anti-retroviral.•M-MDSC expansion is independent of gut dysbiosis in HIV (+) individuals.•IL-6 drives monocytic-MDSC expansion in HIV (+) individuals.•Immune activation pathways differ depending on predominant HIV-subtype. HIV-i...
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Veröffentlicht in: | Cellular immunology 2021-04, Vol.362, p.104304-104304, Article 104304 |
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Sprache: | eng |
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Zusammenfassung: | •M-MDSC persist in HIV (+) individuals despite prolonged treatment with anti-retroviral.•M-MDSC expansion is independent of gut dysbiosis in HIV (+) individuals.•IL-6 drives monocytic-MDSC expansion in HIV (+) individuals.•Immune activation pathways differ depending on predominant HIV-subtype.
HIV-infected individuals on combined antiretroviral therapy (ART) with virologic suppression exhibit sustained immune dysfunction. Our recent work has highlighted that monocytic myeloid derived suppressor cells (M-MDSC) are elevated in these individuals and suppress immune responses. Factors responsible for M-MDSC expansion in vivo are unknown. Here we compared circulating frequency of M-MDSC in HIV-infected persons from the US and India where HIV subtype-B or –C predominate, respectively. We further investigated soluble mediators of residual immune activation in two cohorts and determined their correlation with M-MDSC expansion. Our findings show that M-MDSC are elevated and correlate with plasma levels of IL-6 in both cohorts. Chemokines CXCL10, CCL4 and CXCL8 were also elevated in HIV-infected individuals, but did not correlate with M-MDSC. These findings support that IL-6 is important in M-MDSC expansion which is independent of HIV subtype. |
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ISSN: | 0008-8749 1090-2163 |
DOI: | 10.1016/j.cellimm.2021.104304 |