Residual immune activation in HIV-Infected individuals expands monocytic-myeloid derived suppressor cells

•M-MDSC persist in HIV (+) individuals despite prolonged treatment with anti-retroviral.•M-MDSC expansion is independent of gut dysbiosis in HIV (+) individuals.•IL-6 drives monocytic-MDSC expansion in HIV (+) individuals.•Immune activation pathways differ depending on predominant HIV-subtype. HIV-i...

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Veröffentlicht in:Cellular immunology 2021-04, Vol.362, p.104304-104304, Article 104304
Hauptverfasser: Singh, Ritesh, Chakraborty, Mouli, Gautam, Anuradha, Roy, Suman K., Halder, Indranil, Barber, Jamie, Garg, Ankita
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Sprache:eng
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Zusammenfassung:•M-MDSC persist in HIV (+) individuals despite prolonged treatment with anti-retroviral.•M-MDSC expansion is independent of gut dysbiosis in HIV (+) individuals.•IL-6 drives monocytic-MDSC expansion in HIV (+) individuals.•Immune activation pathways differ depending on predominant HIV-subtype. HIV-infected individuals on combined antiretroviral therapy (ART) with virologic suppression exhibit sustained immune dysfunction. Our recent work has highlighted that monocytic myeloid derived suppressor cells (M-MDSC) are elevated in these individuals and suppress immune responses. Factors responsible for M-MDSC expansion in vivo are unknown. Here we compared circulating frequency of M-MDSC in HIV-infected persons from the US and India where HIV subtype-B or –C predominate, respectively. We further investigated soluble mediators of residual immune activation in two cohorts and determined their correlation with M-MDSC expansion. Our findings show that M-MDSC are elevated and correlate with plasma levels of IL-6 in both cohorts. Chemokines CXCL10, CCL4 and CXCL8 were also elevated in HIV-infected individuals, but did not correlate with M-MDSC. These findings support that IL-6 is important in M-MDSC expansion which is independent of HIV subtype.
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2021.104304