Engineered Biosynthesis of Fungal 4‑Quinolone Natural Products

Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here we uncovered a concise nonribosomal peptide synthetase pathway involved in quinolactacin A biosynt...

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Veröffentlicht in:Organic letters 2020-08, Vol.22 (16), p.6637-6641
Hauptverfasser: Liu, Mengting, Ohashi, Masao, Tang, Yi
Format: Artikel
Sprache:eng
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Zusammenfassung:Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here we uncovered a concise nonribosomal peptide synthetase pathway involved in quinolactacin A biosynthesis from Penicillium by using heterologous reconstitution and in vitro enzymatic synthesis. The N-desmethyl analog of quinolactacin A was accessed through the construction of a hybrid bacterial and fungi pathway in the heterologous host.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c02426