Efficacy and Safety of Coadministered Amlodipine and Atorvastatin in Patients With Hypertension and Dyslipidemia: Results of the AVALON Trial
The AVALON study was a randomized, multicenter trial to assess the efficacy and safety of coadministered amlodipine and atorvastatin in patients with hypertension and dyslipidemia. Phase one was an 8‐week, double‐blind, double‐dummy, placebo‐controlled period whereby patients received amlodipine 5 m...
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Veröffentlicht in: | The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2006-08, Vol.8 (8), p.571-583 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The AVALON study was a randomized, multicenter trial to assess the efficacy and safety of coadministered amlodipine and atorvastatin in patients with hypertension and dyslipidemia. Phase one was an 8‐week, double‐blind, double‐dummy, placebo‐controlled period whereby patients received amlodipine 5 mg, atorvastatin 10 mg, amlodipine 5 mg and atorvastatin 10 mg, or placebo. Thereafter, all patients received single‐blind amlodipine 5 mg and atorvastatin 10 mg for 8‐weeks, followed by 12 weeks of open‐label treatment where doses could be titrated to improve low‐density lipoprotein cholesterol and blood pressure control. A total of 847 patients entered the double‐blind phase. At Week 8, 45% of the patients receiving amlodipine 5 mg and atorvastatin 10 mg reached both their blood pressure and low‐density lipoprotein cholesterol goals, compared with 8.3% with amlodipine (p |
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ISSN: | 1524-6175 1751-7176 |
DOI: | 10.1111/j.1524-6175.2006.05636.x |