Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance
[Display omitted] Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME tec...
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| Veröffentlicht in: | Advanced drug delivery reviews 2021-05, Vol.172, p.52-63 |
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| container_title | Advanced drug delivery reviews |
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| creator | Bandari, Suresh Nyavanandi, Dinesh Dumpa, Nagireddy Repka, Michael A. |
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Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be coupled with FDM 3D printing as a continuous manufacturing process. However, the crucial pharmaceutical polymers, formulation and process parameters must be investigated to establish HME-coupled FDM 3D printing. These advancements will lead the way towards developing continuous drug delivery systems for personalized therapy. This brief overview classifies pharmaceutical additive manufacturing, Hot Melt Extrusion, and Fused Deposition Modeling 3D printing techniques with a focus on coupling HME and FDM 3D printing processes. It also provides insights on the critical material properties, process and equipment parameters and limitations of successful HME-coupled FDM systems. |
| doi_str_mv | 10.1016/j.addr.2021.02.006 |
| format | Article |
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Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be coupled with FDM 3D printing as a continuous manufacturing process. However, the crucial pharmaceutical polymers, formulation and process parameters must be investigated to establish HME-coupled FDM 3D printing. These advancements will lead the way towards developing continuous drug delivery systems for personalized therapy. This brief overview classifies pharmaceutical additive manufacturing, Hot Melt Extrusion, and Fused Deposition Modeling 3D printing techniques with a focus on coupling HME and FDM 3D printing processes. It also provides insights on the critical material properties, process and equipment parameters and limitations of successful HME-coupled FDM systems.</description><identifier>ISSN: 0169-409X</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2021.02.006</identifier><identifier>PMID: 33571550</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>3D printing ; Additive manufacturing ; Continuous manufacturing ; Coupling ; Drug Delivery Systems ; Equipment Design ; Excipients - chemistry ; Fused deposition modeling ; Hot melt extrusion ; Hot Melt Extrusion Technology - methods ; Humans ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - chemistry ; Polymers - chemistry ; Printing, Three-Dimensional ; Process analytical technology ; Technology, Pharmaceutical - methods</subject><ispartof>Advanced drug delivery reviews, 2021-05, Vol.172, p.52-63</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3706-2f1bf870bd3cbbbd02c26499e280ac8436006e3cb2540f37bb242da2e43ced03</citedby><cites>FETCH-LOGICAL-c3706-2f1bf870bd3cbbbd02c26499e280ac8436006e3cb2540f37bb242da2e43ced03</cites><orcidid>0000-0002-3271-5006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169409X21000405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33571550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bandari, Suresh</creatorcontrib><creatorcontrib>Nyavanandi, Dinesh</creatorcontrib><creatorcontrib>Dumpa, Nagireddy</creatorcontrib><creatorcontrib>Repka, Michael A.</creatorcontrib><title>Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>[Display omitted]
Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be coupled with FDM 3D printing as a continuous manufacturing process. However, the crucial pharmaceutical polymers, formulation and process parameters must be investigated to establish HME-coupled FDM 3D printing. These advancements will lead the way towards developing continuous drug delivery systems for personalized therapy. This brief overview classifies pharmaceutical additive manufacturing, Hot Melt Extrusion, and Fused Deposition Modeling 3D printing techniques with a focus on coupling HME and FDM 3D printing processes. 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Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be coupled with FDM 3D printing as a continuous manufacturing process. However, the crucial pharmaceutical polymers, formulation and process parameters must be investigated to establish HME-coupled FDM 3D printing. These advancements will lead the way towards developing continuous drug delivery systems for personalized therapy. This brief overview classifies pharmaceutical additive manufacturing, Hot Melt Extrusion, and Fused Deposition Modeling 3D printing techniques with a focus on coupling HME and FDM 3D printing processes. It also provides insights on the critical material properties, process and equipment parameters and limitations of successful HME-coupled FDM systems.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33571550</pmid><doi>10.1016/j.addr.2021.02.006</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3271-5006</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2021-05, Vol.172, p.52-63 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 3D printing Additive manufacturing Continuous manufacturing Coupling Drug Delivery Systems Equipment Design Excipients - chemistry Fused deposition modeling Hot melt extrusion Hot Melt Extrusion Technology - methods Humans Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Polymers - chemistry Printing, Three-Dimensional Process analytical technology Technology, Pharmaceutical - methods |
| title | Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance |
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