Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors

Evaluation of BRCA1 and BRCA2 as Indicators of Response to Immune Checkpoint Inhibitors

This cohort study examines the association of BRCA1 and BRCA2 with tumor mutation burden and response to immune checkpoint inhibitors.

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Bibliographische Detailangaben
Veröffentlicht in:JAMA network open 2021-05, Vol.4 (5), p.e217728-e217728
Hauptverfasser: Zhou, Zhijun, Li, Min
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers, Tumor - genetics
BRCA1 Protein - genetics
BRCA2 Protein - genetics
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - mortality
Cohort Studies
Female
Humans
Immune Checkpoint Inhibitors - therapeutic use
Kaplan-Meier Estimate
Mutation
Oncology
Online Only
Research Letter
Tumor Burden
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Beschreibung
Zusammenfassung:This cohort study examines the association of BRCA1 and BRCA2 with tumor mutation burden and response to immune checkpoint inhibitors.
ISSN:2574-3805
2574-3805
DOI:10.1001/jamanetworkopen.2021.7728