Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue

In this cluster-randomized trial conducted in Indonesia, deployment of mosquitoes infected with the w Mel strain of Wolbachia pipientis resulted in fewer symptomatic, virologically confirmed dengue infections and hospitalizations among residents.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-06, Vol.384 (23), p.2177-2186
Hauptverfasser:	Utarini, Adi, Indriani, Citra, Ahmad, Riris A, Tantowijoyo, Warsito, Arguni, Eggi, Ansari, M. Ridwan, Supriyati, Endah, Wardana, D. Satria, Meitika, Yeti, Ernesia, Inggrid, Nurhayati, Indah, Prabowo, Equatori, Andari, Bekti, Green, Benjamin R, Hodgson, Lauren, Cutcher, Zoe, Rancès, Edwige, Ryan, Peter A, O’Neill, Scott L, Dufault, Suzanne M, Tanamas, Stephanie K, Jewell, Nicholas P, Anders, Katherine L, Simmons, Cameron P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aedes - microbiology Aedes - virology Animals Antigens Child Child, Preschool Communicable Disease Control - methods Community Culicidae Dengue - diagnosis Dengue - epidemiology Dengue - prevention & control Dengue - transmission Dengue fever Dengue Virus - isolation & purification Enrollments Female Fever Humans Incidence Indonesia - epidemiology Male Middle Aged Mosquito Vectors - microbiology Mosquito Vectors - virology Mosquitoes Population Public health Serotypes Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Statistical analysis Viruses Wolbachia Young Adult Zika virus
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Beschreibung
Zusammenfassung:	In this cluster-randomized trial conducted in Indonesia, deployment of mosquitoes infected with the w Mel strain of Wolbachia pipientis resulted in fewer symptomatic, virologically confirmed dengue infections and hospitalizations among residents.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2030243