Kidney injury biomarkers during exposure to tenofovir-based pre-exposure prophylaxis

We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate among HIV-negative adults randomized to emtricitabine/ tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case-control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between subjects who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.