CASE OF THE MONTH: March 1999 - A 26 Year Old HIV Positive Male with Dura Based Masses

A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neopla...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 1999-07, Vol.9 (3), p.609-610
Hauptverfasser:	Karpinski, Nancy C, Yaghmai, Reza, Barba, David, Hansen, Lawrence A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Actins - metabolism Adult AIDS/HIV Brain Neoplasms - complications Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - virology Case of the Month Herpesvirus 4, Human - isolation & purification Humans Immunohistochemistry In Situ Hybridization Leiomyoma - complications Leiomyoma - metabolism Leiomyoma - pathology Leiomyoma - virology Magnetic Resonance Imaging Male Meningeal Neoplasms - complications Meningeal Neoplasms - metabolism Meningeal Neoplasms - pathology Meningeal Neoplasms - virology
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Zusammenfassung:	A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slender nuclei, consistent with leiomyomas. Both tumors were positive for Epstein Barr virus by in situ hybridization. This case report serves to emphasize the importance of considering soft tissue tumors such as leiomyoma in the differential diagnosis of mass lesions that occur in the central nervous system in AIDS and discusses the role of EBV in tumorigenesis.
ISSN:	1015-6305 1750-3639
DOI:	10.1111/j.1750-3639.1999.tb00609.x