Rifabutin Is Inactivated by Mycobacterium abscessus Arr

Rifabutin Is Inactivated by Mycobacterium abscessus Arr

exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of revealed a strongly decreased MIC. Our findings suggest...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2021-02, Vol.65 (3)
Hauptverfasser: Schäfle, Daniel, Selchow, Petra, Borer, Barbara, Meuli, Michael, Rominski, Anna, Schulthess, Bettina, Sander, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Mechanisms of Resistance
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Zusammenfassung:exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of revealed a strongly decreased MIC. Our findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking Arr activity.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02215-20