Sheep can be used as animal model of regional myocardial remodeling and controllable work
Pacing the right heart has been shown to induce reversible conduction delay and subse-quent asymmetric remodeling of the left ventricle (LV) in dogs and pigs. Both species have disadvantages in animal experiments. Therefore the aim of this study was to develop a more feasible and easy-to-use animal...
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| Veröffentlicht in: | Cardiology journal 2019-01, Vol.26 (4), p.375-384 |
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| creator | Duchenne, Jürgen Claus, Piet Pagourelias, Efstathios D Mada, Razvan O Van Puyvelde, Joeri Vunckx, Kathleen Verbeken, Eric Gheysens, Olivier Rega, Filip Voigt, Jens-Uwe |
| description | Pacing the right heart has been shown to induce reversible conduction delay and subse-quent asymmetric remodeling of the left ventricle (LV) in dogs and pigs. Both species have disadvantages in animal experiments. Therefore the aim of this study was to develop a more feasible and easy-to-use animal model in sheep.
Dual-chamber (DDD) pacemakers with epicardial leads on the right atrium and right ven-tricular free wall were implanted in 13 sheep. All animals underwent 8 weeks of chronic rapid pacing at 180 bpm. Reported observations were made at 110 bpm.
DDD pacing acutely induced a left bundle branch block (LBBB) - like pattern with almost doubling in QRS width and the appearance of a septal flash, indicating mechanical dyssynchrony. Atrial pacing (AAI) resulted in normal ventricular conduction and function. During 8 weeks of rapid DDD pacing, animals developed LV remodeling (confirmed with histology) with septal wall thinning (-30%, p < 0.05), lateral wall thickening (+22%, p < 0.05), LV volume increase (+32%, p < 0.05), decrease of LV ejection fraction (-31%, p < 0.05), and functional mitral regurgitation. After 8 weeks, segmental pressure-strain-loops, representing regional myocardial work, were recorded. Switching from AAI to DDD pacing decreased immediately work in the septum and increased it in the lateral wall (-69 and +41%, respectively, p < 0.05). Global LV stroke work and dP/dtmax decreased (-27% and -25%, respectively, p < 0.05).
This study presents the development a new sheep model with an asymmetrically remod-eled LV. Simple pacemaker programing allows direct modulation of regional myocardial function and work. This animal model provides a new and valuable alternative for canine or porcine models and has the potential to become instrumental for investigating regional function and loading conditions on regional LV remodeling. |
| doi_str_mv | 10.5603/CJ.a2018.0007 |
| format | Article |
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Dual-chamber (DDD) pacemakers with epicardial leads on the right atrium and right ven-tricular free wall were implanted in 13 sheep. All animals underwent 8 weeks of chronic rapid pacing at 180 bpm. Reported observations were made at 110 bpm.
DDD pacing acutely induced a left bundle branch block (LBBB) - like pattern with almost doubling in QRS width and the appearance of a septal flash, indicating mechanical dyssynchrony. Atrial pacing (AAI) resulted in normal ventricular conduction and function. During 8 weeks of rapid DDD pacing, animals developed LV remodeling (confirmed with histology) with septal wall thinning (-30%, p < 0.05), lateral wall thickening (+22%, p < 0.05), LV volume increase (+32%, p < 0.05), decrease of LV ejection fraction (-31%, p < 0.05), and functional mitral regurgitation. After 8 weeks, segmental pressure-strain-loops, representing regional myocardial work, were recorded. Switching from AAI to DDD pacing decreased immediately work in the septum and increased it in the lateral wall (-69 and +41%, respectively, p < 0.05). Global LV stroke work and dP/dtmax decreased (-27% and -25%, respectively, p < 0.05).
This study presents the development a new sheep model with an asymmetrically remod-eled LV. Simple pacemaker programing allows direct modulation of regional myocardial function and work. This animal model provides a new and valuable alternative for canine or porcine models and has the potential to become instrumental for investigating regional function and loading conditions on regional LV remodeling.]]></description><identifier>ISSN: 1897-5593</identifier><identifier>EISSN: 1897-5593</identifier><identifier>EISSN: 1898-018X</identifier><identifier>DOI: 10.5603/CJ.a2018.0007</identifier><identifier>PMID: 29570208</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Action Potentials ; Animals ; Basic Science and Experimental Cardiology ; Bundle-Branch Block - diagnosis ; Bundle-Branch Block - etiology ; Bundle-Branch Block - physiopathology ; Cardiac Pacing, Artificial ; Disease Models, Animal ; Disease Progression ; Heart Conduction System - physiopathology ; Heart Rate ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - physiopathology ; Male ; Mitral Valve Insufficiency - etiology ; Mitral Valve Insufficiency - physiopathology ; Sheep ; Sheep, Domestic ; Stroke Volume ; Time Factors ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left ; Ventricular Pressure ; Ventricular Remodeling</subject><ispartof>Cardiology journal, 2019-01, Vol.26 (4), p.375-384</ispartof><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2019 Via Medica 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-6667a707a878dfed215604abdb5ed25828099e7d7e1e2e25e9a02d2dae0e70393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084358/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084358/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29570208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duchenne, Jürgen</creatorcontrib><creatorcontrib>Claus, Piet</creatorcontrib><creatorcontrib>Pagourelias, Efstathios D</creatorcontrib><creatorcontrib>Mada, Razvan O</creatorcontrib><creatorcontrib>Van Puyvelde, Joeri</creatorcontrib><creatorcontrib>Vunckx, Kathleen</creatorcontrib><creatorcontrib>Verbeken, Eric</creatorcontrib><creatorcontrib>Gheysens, Olivier</creatorcontrib><creatorcontrib>Rega, Filip</creatorcontrib><creatorcontrib>Voigt, Jens-Uwe</creatorcontrib><title>Sheep can be used as animal model of regional myocardial remodeling and controllable work</title><title>Cardiology journal</title><addtitle>Cardiol J</addtitle><description><![CDATA[Pacing the right heart has been shown to induce reversible conduction delay and subse-quent asymmetric remodeling of the left ventricle (LV) in dogs and pigs. Both species have disadvantages in animal experiments. Therefore the aim of this study was to develop a more feasible and easy-to-use animal model in sheep.
Dual-chamber (DDD) pacemakers with epicardial leads on the right atrium and right ven-tricular free wall were implanted in 13 sheep. All animals underwent 8 weeks of chronic rapid pacing at 180 bpm. Reported observations were made at 110 bpm.
DDD pacing acutely induced a left bundle branch block (LBBB) - like pattern with almost doubling in QRS width and the appearance of a septal flash, indicating mechanical dyssynchrony. Atrial pacing (AAI) resulted in normal ventricular conduction and function. During 8 weeks of rapid DDD pacing, animals developed LV remodeling (confirmed with histology) with septal wall thinning (-30%, p < 0.05), lateral wall thickening (+22%, p < 0.05), LV volume increase (+32%, p < 0.05), decrease of LV ejection fraction (-31%, p < 0.05), and functional mitral regurgitation. After 8 weeks, segmental pressure-strain-loops, representing regional myocardial work, were recorded. Switching from AAI to DDD pacing decreased immediately work in the septum and increased it in the lateral wall (-69 and +41%, respectively, p < 0.05). Global LV stroke work and dP/dtmax decreased (-27% and -25%, respectively, p < 0.05).
This study presents the development a new sheep model with an asymmetrically remod-eled LV. Simple pacemaker programing allows direct modulation of regional myocardial function and work. This animal model provides a new and valuable alternative for canine or porcine models and has the potential to become instrumental for investigating regional function and loading conditions on regional LV remodeling.]]></description><subject>Action Potentials</subject><subject>Animals</subject><subject>Basic Science and Experimental Cardiology</subject><subject>Bundle-Branch Block - diagnosis</subject><subject>Bundle-Branch Block - etiology</subject><subject>Bundle-Branch Block - physiopathology</subject><subject>Cardiac Pacing, Artificial</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart Rate</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Male</subject><subject>Mitral Valve Insufficiency - etiology</subject><subject>Mitral Valve Insufficiency - physiopathology</subject><subject>Sheep</subject><subject>Sheep, Domestic</subject><subject>Stroke Volume</subject><subject>Time Factors</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Pressure</subject><subject>Ventricular Remodeling</subject><issn>1897-5593</issn><issn>1897-5593</issn><issn>1898-018X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkb1PwzAQxS0E4qMwsiJLLCwpFyeO7QUJVXxVSAzAwGQ58bUNpHGxG1D_exwoCJh89v30fO8eIYcpDHkB2eloPDQMUjkEALFBdlOpRMK5yjZ_1TtkL4RngEJxzrbJDlNcAAO5S57uZ4gLWpmWlki7gJaaQE1bz01D585iQ92EepzWru1fVq4y3tax9PjZrttpxC2tXLv0rmlM2SB9d_5ln2xNTBPwYH0OyOPlxcPoOrm9u7oZnd8mVc7VMimKQhgBwkgh7QQtS6Ot3JS25PHCJZOgFAorMEWGjKMywCyzBgEFZCobkLMv3UVXztFWGOcwjV74aMGvtDO1_ttp65meujctQeYZl1HgZC3g3WuHYanndagwWmnRdUH324W0yPP-r-N_6LPrfFxMpPIiZ1AwJSKVfFGVdyF4nPwMk4LuQ9Ojsf4MTfehRf7ot4Mf-jul7APlOpLQ</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Duchenne, Jürgen</creator><creator>Claus, Piet</creator><creator>Pagourelias, Efstathios D</creator><creator>Mada, Razvan O</creator><creator>Van Puyvelde, Joeri</creator><creator>Vunckx, Kathleen</creator><creator>Verbeken, Eric</creator><creator>Gheysens, Olivier</creator><creator>Rega, Filip</creator><creator>Voigt, Jens-Uwe</creator><general>Wydawnictwo Via Medica</general><general>Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Sheep can be used as animal model of regional myocardial remodeling and controllable work</title><author>Duchenne, Jürgen ; Claus, Piet ; Pagourelias, Efstathios D ; Mada, Razvan O ; Van Puyvelde, Joeri ; Vunckx, Kathleen ; Verbeken, Eric ; Gheysens, Olivier ; Rega, Filip ; Voigt, Jens-Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-6667a707a878dfed215604abdb5ed25828099e7d7e1e2e25e9a02d2dae0e70393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Basic Science and Experimental Cardiology</topic><topic>Bundle-Branch Block - diagnosis</topic><topic>Bundle-Branch Block - etiology</topic><topic>Bundle-Branch Block - physiopathology</topic><topic>Cardiac Pacing, Artificial</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart Rate</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Male</topic><topic>Mitral Valve Insufficiency - etiology</topic><topic>Mitral Valve Insufficiency - physiopathology</topic><topic>Sheep</topic><topic>Sheep, Domestic</topic><topic>Stroke Volume</topic><topic>Time Factors</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Pressure</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duchenne, Jürgen</creatorcontrib><creatorcontrib>Claus, Piet</creatorcontrib><creatorcontrib>Pagourelias, Efstathios D</creatorcontrib><creatorcontrib>Mada, Razvan O</creatorcontrib><creatorcontrib>Van Puyvelde, Joeri</creatorcontrib><creatorcontrib>Vunckx, Kathleen</creatorcontrib><creatorcontrib>Verbeken, Eric</creatorcontrib><creatorcontrib>Gheysens, Olivier</creatorcontrib><creatorcontrib>Rega, Filip</creatorcontrib><creatorcontrib>Voigt, Jens-Uwe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duchenne, Jürgen</au><au>Claus, Piet</au><au>Pagourelias, Efstathios D</au><au>Mada, Razvan O</au><au>Van Puyvelde, Joeri</au><au>Vunckx, Kathleen</au><au>Verbeken, Eric</au><au>Gheysens, Olivier</au><au>Rega, Filip</au><au>Voigt, Jens-Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sheep can be used as animal model of regional myocardial remodeling and controllable work</atitle><jtitle>Cardiology journal</jtitle><addtitle>Cardiol J</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>26</volume><issue>4</issue><spage>375</spage><epage>384</epage><pages>375-384</pages><issn>1897-5593</issn><eissn>1897-5593</eissn><eissn>1898-018X</eissn><abstract><![CDATA[Pacing the right heart has been shown to induce reversible conduction delay and subse-quent asymmetric remodeling of the left ventricle (LV) in dogs and pigs. Both species have disadvantages in animal experiments. Therefore the aim of this study was to develop a more feasible and easy-to-use animal model in sheep.
Dual-chamber (DDD) pacemakers with epicardial leads on the right atrium and right ven-tricular free wall were implanted in 13 sheep. All animals underwent 8 weeks of chronic rapid pacing at 180 bpm. Reported observations were made at 110 bpm.
DDD pacing acutely induced a left bundle branch block (LBBB) - like pattern with almost doubling in QRS width and the appearance of a septal flash, indicating mechanical dyssynchrony. Atrial pacing (AAI) resulted in normal ventricular conduction and function. During 8 weeks of rapid DDD pacing, animals developed LV remodeling (confirmed with histology) with septal wall thinning (-30%, p < 0.05), lateral wall thickening (+22%, p < 0.05), LV volume increase (+32%, p < 0.05), decrease of LV ejection fraction (-31%, p < 0.05), and functional mitral regurgitation. After 8 weeks, segmental pressure-strain-loops, representing regional myocardial work, were recorded. Switching from AAI to DDD pacing decreased immediately work in the septum and increased it in the lateral wall (-69 and +41%, respectively, p < 0.05). Global LV stroke work and dP/dtmax decreased (-27% and -25%, respectively, p < 0.05).
This study presents the development a new sheep model with an asymmetrically remod-eled LV. Simple pacemaker programing allows direct modulation of regional myocardial function and work. This animal model provides a new and valuable alternative for canine or porcine models and has the potential to become instrumental for investigating regional function and loading conditions on regional LV remodeling.]]></abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>29570208</pmid><doi>10.5603/CJ.a2018.0007</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cardiology journal, 2019-01, Vol.26 (4), p.375-384 |
| issn | 1897-5593 1897-5593 1898-018X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8084358 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Action Potentials Animals Basic Science and Experimental Cardiology Bundle-Branch Block - diagnosis Bundle-Branch Block - etiology Bundle-Branch Block - physiopathology Cardiac Pacing, Artificial Disease Models, Animal Disease Progression Heart Conduction System - physiopathology Heart Rate Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - physiopathology Male Mitral Valve Insufficiency - etiology Mitral Valve Insufficiency - physiopathology Sheep Sheep, Domestic Stroke Volume Time Factors Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Pressure Ventricular Remodeling |
| title | Sheep can be used as animal model of regional myocardial remodeling and controllable work |
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