Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic...

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Veröffentlicht in:	Open Forum Infectious Diseases 2021-08, Vol.8 (8), p.ofab153-ofab153
Hauptverfasser:	Regan, James, Flynn, James P, Rosenthal, Alexandra, Jordan, Hannah, Li, Yijia, Chishti, Rida, Giguel, Francoise, Corry, Heather, Coxen, Kendyll, Fajnzylber, Jesse, Gillespie, Elizabeth, Kuritzkes, Daniel R, Hacohen, Nir, Goldberg, Marcia B, Filbin, Michael R, Yu, Xu G, Baden, Lindsey, Ribeiro, Ruy M, Perelson, Alan S, Conway, Jessica M, Li, Jonathan Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Brief Reports Coronaviruses Disease transmission Health aspects Medical research Medicine, Experimental RNA Severe acute respiratory syndrome
Online-Zugang:	Volltext
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Zusammenfassung:	Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.
ISSN:	2328-8957 2328-8957
DOI:	10.1093/ofid/ofab153