Prognostic Value of the Neutrophil-to-Lymphocyte Ratio before and after Radiotherapy for Anaplastic Thyroid Carcinoma

Prognostic Value of the Neutrophil-to-Lymphocyte Ratio before and after Radiotherapy for Anaplastic Thyroid Carcinoma

The neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation, and its elevation has recently been associated with poor survival in many solid cancers. Leukocyte elevation and lymphocyte reduction are associated with a poor response to radiotherapy (RT). This study aimed to assess the p...

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Veröffentlicht in:Cancers 2021-04, Vol.13 (8), p.1913
Hauptverfasser: Park, Jiyun, Park, Jun, Shin, Jung-Hee, Oh, Young-Lyun, Jung, Hyun-Ae, Chung, Man-Ki, Choe, Jun-Ho, Ahn, Yong-Chan, Kim, Sun-Wook, Chung, Jae-Hoon, Kim, Tae-Hyuk, Noh, Jae-Myoung
Format: Artikel
Sprache:eng
Schlagworte:
Cancer therapies
Chemotherapy
Cytotoxicity
Hematology
Immune system
Inflammation
Leukocytes (neutrophilic)
Lymphocytes
Medical prognosis
Neutrophils
Patients
Radiation therapy
Surgery
Thyroid cancer
Thyroid carcinoma
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Zusammenfassung:The neutrophil-lymphocyte ratio (NLR) is a marker of systemic inflammation, and its elevation has recently been associated with poor survival in many solid cancers. Leukocyte elevation and lymphocyte reduction are associated with a poor response to radiotherapy (RT). This study aimed to assess the prognostic value of NLR before and after RT for anaplastic thyroid carcinoma (ATC). This retrospective study analyzed 40 patients with ATC who received RT with available complete blood cell count data from November 1995 through May 2020 at Samsung Medical Center (Seoul, Korea). Patients were classified into two groups according to the NLR before and after RT. The median overall survival (OS) was 8.9 months (range, 3.5-18.2) in the low NLR group (
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13081913