Short term survival of critically ill COVID-19 Egyptian patients on assisted ventilation treated by either Dexamethasone or Tocilizumab

Tocilizumab (TCZ) and Dexamethasone are used for the treatment of critically ill COVID-19 patients. We compared the short-term survival of critically ill COVID-19 patients treated with either TCZ or Dexamethasone. 109 critically ill COVID-19 patients randomly assigned to either TCZ therapy (46 patie...

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Veröffentlicht in:Scientific reports 2021-04, Vol.11 (1), p.8816-8816, Article 8816
Hauptverfasser: Rashad, Alaa, Mousa, Sherif, Nafady-Hego, Hanaa, Nafady, Asmaa, Elgendy, Hamed
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Sprache:eng
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Zusammenfassung:Tocilizumab (TCZ) and Dexamethasone are used for the treatment of critically ill COVID-19 patients. We compared the short-term survival of critically ill COVID-19 patients treated with either TCZ or Dexamethasone. 109 critically ill COVID-19 patients randomly assigned to either TCZ therapy (46 patients) or pulse Dexamethasone therapy (63 patients). Age, sex, neutrophil/ lymphocyte ratio, D-dimer, ferritin level, and CT chest pattern were comparable between groups. Kaplan–Meier survival analysis showed better survival in Dexamethasone group compared with TCZ ( P  = 0.002), patients didn’t need vasopressor at admission ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-88086-x