Proteomics signature of autoimmune atrophic gastritis: towards a link with gastric cancer

Background Autoimmune atrophic gastritis (AAG) is a chronic disease that can progress to gastric cancer (GC). To better understand AAG pathology, this proteomics study investigated gastric proteins whose expression levels are altered in this disease and also in GC. Methods Using two-dimensional diff...

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Veröffentlicht in:	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2021-05, Vol.24 (3), p.666-679
Hauptverfasser:	Repetto, Ombretta, De Re, Valli, Giuffrida, Paolo, Lenti, Marco Vincenzo, Magris, Raffaella, Venerito, Marino, Steffan, Agostino, Di Sabatino, Antonio, Cannizzaro, Renato
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adult Biopsy Cancer Research Female Gastric cancer Gastritis Gastritis, Atrophic - complications Gastroenterology Gel electrophoresis Gene mapping Helicobacter Infections - complications Helicobacter pylori Humans Immunoblotting Male Medicine Medicine & Public Health Middle Aged Oncology Original Original Article Precancerous Conditions - complications Proteins Proteomics Stomach Neoplasms - etiology Stomach Neoplasms - pathology Surgical Oncology Tricarboxylic acid cycle
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Zusammenfassung:	Background Autoimmune atrophic gastritis (AAG) is a chronic disease that can progress to gastric cancer (GC). To better understand AAG pathology, this proteomics study investigated gastric proteins whose expression levels are altered in this disease and also in GC. Methods Using two-dimensional difference gel electrophoresis (2D-DIGE), we compared protein maps of gastric corpus biopsies from AAG patients and controls. Differentially abundant spots (\|fold change\|≥ 1.5, P
ISSN:	1436-3291 1436-3305
DOI:	10.1007/s10120-020-01148-3