Cytocompatibility of Ti–xZr alloys as dental implant materials

Ti–xZr ( x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogeni...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2021-05, Vol.32 (5), p.50, Article 50
Hauptverfasser:	Ou, Pinghua, Hao, Cong, Liu, Jue, He, Rengui, Wang, Baoqi, Ruan, Jianming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloys Biocompatibility Biocompatibility Studies Biomaterials Biomechanics Biomedical Engineering and Bioengineering Biomedical materials Ceramics Chemistry and Materials Science Cholecystokinin Composites Cytotoxicity Dental alloys Dental implants Dental materials Dental prosthetics Electron microscopy Glass Materials Science Mechanical properties Modulus of elasticity Natural Materials Polymer Sciences Regenerative Medicine/Tissue Engineering Surfaces and Interfaces Surgical implants Thin Films Titanium Toxicity Transplants & implants
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Zusammenfassung:	Ti–xZr ( x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti–xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti–45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.
ISSN:	0957-4530 1573-4838
DOI:	10.1007/s10856-021-06522-w