Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy

Abstract Context The rate of glucose metabolism changes drastically after partial pancreatectomy. Objective This work aims to analyze changes in patients’ glucose metabolism and endocrine and exocrine function before and after partial pancreatectomy relative to different resection types (Kindai Pros...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2021-05, Vol.106 (5), p.e2203-e2214
Hauptverfasser: Niwano, Fumimaru, Babaya, Naru, Hiromine, Yoshihisa, Matsumoto, Ippei, Kamei, Keiko, Noso, Shinsuke, Taketomo, Yasunori, Takeyama, Yoshifumi, Kawabata, Yumiko, Ikegami, Hiroshi
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Sprache:eng
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Zusammenfassung:Abstract Context The rate of glucose metabolism changes drastically after partial pancreatectomy. Objective This work aims to analyze changes in patients’ glucose metabolism and endocrine and exocrine function before and after partial pancreatectomy relative to different resection types (Kindai Prospective Study on Metabolism and Endocrinology after Pancreatectomy: KIP-MEP study). Methods A series of 278 consecutive patients with scheduled pancreatectomy were enrolled into our prospective study. Of them, 109 individuals without diabetes, who underwent partial pancreatectomy, were investigated. Data were compared between patients with pancreaticoduodenectomy (PD, n = 73) and those with distal pancreatectomy (DP, n = 36). Results Blood glucose levels during the 75-g oral glucose tolerance test (75gOGTT) significantly decreased after pancreatectomy in the PD group (area under the curve [AUC] –9.3%, P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab036