Genetic markers for preeclampsia in Peruvian women

Background: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbimortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. Objective:...

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Veröffentlicht in:COLOMBIA MEDICA 2021-02, Vol.52 (1), p.e2014437, Article 2014437
Hauptverfasser: Pacheco-Romero, Jose, Acosta Conchucos, Oscar, Huerta Canales, Doris, Cabrera Ramos, Santiago, Vargas Chavez, Marlene, Mascaro Sanchez, Pedro, Huaman Guerrero, Moises, Sandoval Paredes, Jose, Lopez Gabriel, Rudy, Mateus, Julio, Gil Guevara, Enrique, Guevara Rios, Enrique, Butrica Ferre, Nitza, Catari Soto, Diana, Bellido Yarleque, David, Custodio Gonzales, Gina, Naranjo Andonaire, Andrea
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Sprache:eng
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Zusammenfassung:Background: Preeclampsia is a multiorgan disorder associated with maternal and perinatal morbimortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms. Objective: To determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6) -174 G/C, IL-1 beta-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women. Methods: Were included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared. Results: No association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the -174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the -511 C/T polymorphism of the IL-1 beta gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls. Conclusion: No association was found between the studied genetic markers and preeclampsia. However, in the -174G/C polymorphism of the IL-6 gene, significant differences were found mainly in the GG genotype and G allele.
ISSN:1657-9534
0120-8322
1657-9534
DOI:10.25100/cm.v52i1.4437