CDX2 regulates ACE expression in blood development and leukemia cells

CDX2 regulates ACE expression in blood development and leukemia cells

•Expression of caudal-related homeobox gene 2 (CDX2) and angiotensin-converting enzyme (ACE) correlates during hematopoietic emergence.•This emergence occurs in human and mouse embryos and in human acute myeloid leukemia; CDX2 homeoprotein also binds to the ACE promoter.

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Veröffentlicht in:Blood advances 2021-04, Vol.5 (7), p.2012-2016
Hauptverfasser: El Omar, Reine, Julien, Emmanuelle, Biasch, Katia, Guffroy, Blandine, Lioure, Bruno, Vallat, Laurent, Gross, Isabelle, Domon-Dell, Claire, Lanza, François, Gachet, Christian, Negroni, Matteo, Freund, Jean-Noël, Tavian, Manuela
Format: Artikel
Sprache:eng
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Life Sciences
Stimulus Report
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Zusammenfassung:•Expression of caudal-related homeobox gene 2 (CDX2) and angiotensin-converting enzyme (ACE) correlates during hematopoietic emergence.•This emergence occurs in human and mouse embryos and in human acute myeloid leukemia; CDX2 homeoprotein also binds to the ACE promoter.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2020003563