Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Abstract Vertebrate genomes contain major (>99.5%) and minor (

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Bibliographische Detailangaben
Veröffentlicht in:	Nucleic acids research 2021-04, Vol.49 (6), p.3524-3545
Hauptverfasser:	Olthof, Anouk M, White, Alisa K, Mieruszynski, Stephen, Doggett, Karen, Lee, Madisen F, Chakroun, Almahdi, Abdel Aleem, Alice K, Rousseau, Justine, Magnani, Cinzia, Roifman, Chaim M, Campeau, Philippe M, Heath, Joan K, Kanadia, Rahul N
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Apoptosis Regulatory Proteins - metabolism Cardiomyopathies - genetics Cells, Cultured Cerebellar Ataxia - genetics Exons Growth Disorders - genetics Humans Intellectual Disability - genetics Introns Mental Retardation, X-Linked - genetics Mice Microcephaly - genetics Nonsense Mediated mRNA Decay Osteochondrodysplasias - genetics Polyribosomes - metabolism Primary Immunodeficiency Diseases - genetics Retinal Diseases - genetics RNA and RNA-protein complexes RNA, Small Nuclear - antagonists & inhibitors Spliceosomes - metabolism Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	Abstract Vertebrate genomes contain major (>99.5%) and minor (
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/gkab118