Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System

Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System

Ependymomas originate in posterior fossa (PF), supratentorial (ST) or spinal cord (SC) compartments. At present, grading schemes are applied independent of anatomic site. We performed detailed histological examination on 238 World Health Organization grade II and III ependymomas. Among PF ependymoma...

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Veröffentlicht in:Brain pathology (Zurich, Switzerland) Switzerland), 2013-09, Vol.23 (5), p.584-594
Hauptverfasser: Raghunathan, Aditya, Wani, Khalida, Armstrong, Terri S., Vera-Bolanos, Elizabeth, Fouladi, Maryam, Gilbertson, Richard, Gajjar, Amar, Goldman, Stewart, Lehman, Norman L., Metellus, Phillipe, Mikkelsen, Tom, Necesito-Reyes, Mary Jo T., Omuro, Antonio, Packer, Roger J., Partap, Sonia, Pollack, Ian F., Prados, Michael D., Robins, H. Ian, Soffietti, Riccardo, Wu, Jing, Miller, C. Ryan, Gilbert, Mark R., Aldape, Kenneth D.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Central Nervous System - pathology
Central Nervous System Neoplasms - diagnosis
Central Nervous System Neoplasms - mortality
Child
Child, Preschool
Disease-Free Survival
ependymoma
Ependymoma - diagnosis
Ependymoma - mortality
Female
histology
Humans
Infant
Infant, Newborn
Male
Middle Aged
Predictive Value of Tests
progression-free survival
Survival Rate
Tumors
Young Adult
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Zusammenfassung:Ependymomas originate in posterior fossa (PF), supratentorial (ST) or spinal cord (SC) compartments. At present, grading schemes are applied independent of anatomic site. We performed detailed histological examination on 238 World Health Organization grade II and III ependymomas. Among PF ependymomas, the presence of hypercellular areas, necrosis, microvascular proliferation and elevated mitotic rate (all P 
ISSN:1015-6305
1750-3639
DOI:10.1111/bpa.12050