Different role of MSLN and CA125 co-expression as a prognostic predictor between perihilar and distal bile duct carcinoma

Different role of MSLN and CA125 co-expression as a prognostic predictor between perihilar and distal bile duct carcinoma

Recent studies have suggested that the interaction of mesothelin (MSLN) and cancer antigen 125 (CA125) enhances tumor metastases. The aim of the present study was to clarify the impact of MSLN and CA125 co-expression on the prognosis of patients with extrahepatic bile duct carcinoma (BDC). Tissue sa...

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Veröffentlicht in:Oncology letters 2021-05, Vol.21 (5), p.414-414, Article 414
Hauptverfasser: Takihata, Yasuhiro, Einama, Takahiro, Kobayashi, Kazuki, Suzuki, Takafumi, Yonamine, Naoto, Fujinuma, Ibuki, Tsunenari, Takazumi, Yamagishi, Yoji, Iwasaki, Toshimitsu, Miyata, Yoichi, Shinto, Eiji, Ogata, Sho, Tsujimoto, Hironori, Ueno, Hideki, Kishi, Yoji
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Antigens
Cancer
Carcinoma
Cholangiocarcinoma
Cloning
Lymphatic system
Medical prognosis
Metastasis
Motility
Ovarian cancer
Pancreatic cancer
Prognosis
Tumors
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Zusammenfassung:Recent studies have suggested that the interaction of mesothelin (MSLN) and cancer antigen 125 (CA125) enhances tumor metastases. The aim of the present study was to clarify the impact of MSLN and CA125 co-expression on the prognosis of patients with extrahepatic bile duct carcinoma (BDC). Tissue samples from patients who underwent surgical resection between 2007 and 2015 for perihilar or distal BDC were immunohistochemically examined. The expression levels of MSLN and CA125 in tumor cells were analyzed. The expression in
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2021.12675