AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

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Veröffentlicht in:Journal of the American Chemical Society 2020-04, Vol.142 (13), p.5985-5990
Hauptverfasser: Acevedo-Jake, Amanda, Ball, Andrew T, Galli, Marzia, Kukwikila, Mikiembo, Denis, Mathieu, Singleton, Daniel G, Tavassoli, Ali, Goldup, Stephen M
Format: Artikel
Sprache:eng
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Zusammenfassung:We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.0c01670