Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine

Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine

Reported results of immunization with SARS-CoV-2 vaccine have focused on two doses given to seronegative persons. In a small study involving health care workers, antibody responses were examined after a single dose of vaccine. Consistent increases in antibodies to spike protein subunits S1 and S2 an...

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Veröffentlicht in:The New England journal of medicine 2021-05, Vol.384 (20), p.1959-1961
Hauptverfasser: Bradley, Todd, Grundberg, Elin, Selvarangan, Rangaraj, LeMaster, Cas, Fraley, Elizabeth, Banerjee, Dithi, Belden, Bradley, Louiselle, Daniel, Nolte, Nick, Biswell, Rebecca, Pastinen, Tomi, Myers, Angela, Schuster, Jennifer
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antigens
Coronaviruses
Correspondence
COVID-19
FDA approval
Health care
Immunization
Infections
Medical personnel
mRNA
mRNA vaccines
Proteins
Severe acute respiratory syndrome coronavirus 2
Spike protein
Vaccines
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Beschreibung
Zusammenfassung:Reported results of immunization with SARS-CoV-2 vaccine have focused on two doses given to seronegative persons. In a small study involving health care workers, antibody responses were examined after a single dose of vaccine. Consistent increases in antibodies to spike protein subunits S1 and S2 and the receptor-binding domain were noted.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc2102051