A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases
Primary signet-ring cell carcinoma of the uterine cervix (PSRCCC) is defined as a mucinous carcinoma. PSRCCC with independent bilateral ovarian metastases has not been previously reported in the literature. Herein we describe a case of PSRCCC with ovarian involvement. The patient underwent a detaile...
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| Veröffentlicht in: | OncoTargets and therapy 2021-01, Vol.14, p.2101-2107 |
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| creator | Li, Shiyun Gan, Fuqiang Luo, Manling Luo, Puying |
| description | Primary signet-ring cell carcinoma of the uterine cervix (PSRCCC) is defined as a mucinous carcinoma. PSRCCC with independent bilateral ovarian metastases has not been previously reported in the literature.
Herein we describe a case of PSRCCC with ovarian involvement. The patient underwent a detailed complete physical examination, and surgery was then performed to resect all of the tumors. All tumors expressed human papillomavirus 18 no distant tumors were detected, and estrogen receptor and progesterone receptor testing were negative, suggesting that the cervix was the primary site.
This is the first report of a case of PSRCCC metastasis to bilateral ovaries only. Conservative management of human papillomavirus-associated type endocervical adenocarcinomas with independent ovarian metastases should be considered. |
| doi_str_mv | 10.2147/OTT.S300424 |
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Herein we describe a case of PSRCCC with ovarian involvement. The patient underwent a detailed complete physical examination, and surgery was then performed to resect all of the tumors. All tumors expressed human papillomavirus 18 no distant tumors were detected, and estrogen receptor and progesterone receptor testing were negative, suggesting that the cervix was the primary site.
This is the first report of a case of PSRCCC metastasis to bilateral ovaries only. Conservative management of human papillomavirus-associated type endocervical adenocarcinomas with independent ovarian metastases should be considered.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/OTT.S300424</identifier><identifier>PMID: 33790573</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Abdomen ; Antigens ; Cancer ; Carcinoma ; Case Report ; Case reports ; Cervical cancer ; Cervical carcinoma ; Cervix ; Classification ; Estrogen ; Estrogen receptors ; Estrogens ; Fallopian tubes ; Gynecology ; Human papillomavirus ; Informed consent ; Lymphatic system ; Magnetic resonance imaging ; Metastases ; Metastasis ; Obstetrics ; Ovarian cancer ; Papillomavirus infections ; Polymerase chain reaction ; Progesterone ; Surgery ; Tumors ; Uterus ; Vagina</subject><ispartof>OncoTargets and therapy, 2021-01, Vol.14, p.2101-2107</ispartof><rights>2021 Li et al.</rights><rights>COPYRIGHT 2021 Dove Medical Press Limited</rights><rights>2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Li et al. 2021 Li et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b558b5e6835d66abc3ee4e1faf03f88d7898ad43bc03594e8771a4db14367ffd3</citedby><cites>FETCH-LOGICAL-c474t-b558b5e6835d66abc3ee4e1faf03f88d7898ad43bc03594e8771a4db14367ffd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001646/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001646/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33790573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shiyun</creatorcontrib><creatorcontrib>Gan, Fuqiang</creatorcontrib><creatorcontrib>Luo, Manling</creatorcontrib><creatorcontrib>Luo, Puying</creatorcontrib><title>A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>Primary signet-ring cell carcinoma of the uterine cervix (PSRCCC) is defined as a mucinous carcinoma. PSRCCC with independent bilateral ovarian metastases has not been previously reported in the literature.
Herein we describe a case of PSRCCC with ovarian involvement. The patient underwent a detailed complete physical examination, and surgery was then performed to resect all of the tumors. All tumors expressed human papillomavirus 18 no distant tumors were detected, and estrogen receptor and progesterone receptor testing were negative, suggesting that the cervix was the primary site.
This is the first report of a case of PSRCCC metastasis to bilateral ovaries only. Conservative management of human papillomavirus-associated type endocervical adenocarcinomas with independent ovarian metastases should be considered.</description><subject>Abdomen</subject><subject>Antigens</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Cervical cancer</subject><subject>Cervical carcinoma</subject><subject>Cervix</subject><subject>Classification</subject><subject>Estrogen</subject><subject>Estrogen receptors</subject><subject>Estrogens</subject><subject>Fallopian tubes</subject><subject>Gynecology</subject><subject>Human papillomavirus</subject><subject>Informed consent</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Obstetrics</subject><subject>Ovarian cancer</subject><subject>Papillomavirus infections</subject><subject>Polymerase chain reaction</subject><subject>Progesterone</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Uterus</subject><subject>Vagina</subject><issn>1178-6930</issn><issn>1178-6930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkt-LEzEQxxdRvB_65LsEBF9ka9Jkk6wPQi2nHpxU7upzyGZntzl2k5pkK_ffG2k9W5CEyZB85stM-BbFK4Jnc8LE-9V6PbujGLM5e1KcEyJkyWuKnx7lZ8VFjPcYcy7n7HlxRqmocSXoeTEt0K0OgJY6AvId-h7sqMMDurO9g1TeWtejJQxDDmFnjc6JDsY6P-oP6EqHIaNJ94B-2bRB166FLeTgEvpkB50g5IrVTgerHfoGSce8Ib4onnV6iPDycF4WPz5frZdfy5vVl-vl4qY0TLBUNlUlmwq4pFXLuW4MBWBAOt1h2knZCllL3TLaGEyrmoEUgmjWNoRRLrqupZfFx73udmpGaE3uKzektvshlddWnb44u1G93ymJMeGMZ4E3B4Hgf04Qk7r3U3C5ZzWvCK0kl6z-R_V6AGVd57OYGW00asF5zYioa5yp2X-ovFoYrfEOOpvvTwreHhVsQA9pE_0wJetdPAXf7UETfIwBuscJCVZ_PKKyR9TBI5l-ffwpj-xfU9Df3I-2KQ</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Li, Shiyun</creator><creator>Gan, Fuqiang</creator><creator>Luo, Manling</creator><creator>Luo, Puying</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases</title><author>Li, Shiyun ; Gan, Fuqiang ; Luo, Manling ; Luo, Puying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b558b5e6835d66abc3ee4e1faf03f88d7898ad43bc03594e8771a4db14367ffd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdomen</topic><topic>Antigens</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Cervical cancer</topic><topic>Cervical carcinoma</topic><topic>Cervix</topic><topic>Classification</topic><topic>Estrogen</topic><topic>Estrogen receptors</topic><topic>Estrogens</topic><topic>Fallopian tubes</topic><topic>Gynecology</topic><topic>Human papillomavirus</topic><topic>Informed consent</topic><topic>Lymphatic system</topic><topic>Magnetic resonance imaging</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Obstetrics</topic><topic>Ovarian cancer</topic><topic>Papillomavirus infections</topic><topic>Polymerase chain reaction</topic><topic>Progesterone</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Uterus</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shiyun</creatorcontrib><creatorcontrib>Gan, Fuqiang</creatorcontrib><creatorcontrib>Luo, Manling</creatorcontrib><creatorcontrib>Luo, Puying</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>OncoTargets and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shiyun</au><au>Gan, Fuqiang</au><au>Luo, Manling</au><au>Luo, Puying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases</atitle><jtitle>OncoTargets and therapy</jtitle><addtitle>Onco Targets Ther</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>14</volume><spage>2101</spage><epage>2107</epage><pages>2101-2107</pages><issn>1178-6930</issn><eissn>1178-6930</eissn><abstract>Primary signet-ring cell carcinoma of the uterine cervix (PSRCCC) is defined as a mucinous carcinoma. PSRCCC with independent bilateral ovarian metastases has not been previously reported in the literature.
Herein we describe a case of PSRCCC with ovarian involvement. The patient underwent a detailed complete physical examination, and surgery was then performed to resect all of the tumors. All tumors expressed human papillomavirus 18 no distant tumors were detected, and estrogen receptor and progesterone receptor testing were negative, suggesting that the cervix was the primary site.
This is the first report of a case of PSRCCC metastasis to bilateral ovaries only. Conservative management of human papillomavirus-associated type endocervical adenocarcinomas with independent ovarian metastases should be considered.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>33790573</pmid><doi>10.2147/OTT.S300424</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abdomen Antigens Cancer Carcinoma Case Report Case reports Cervical cancer Cervical carcinoma Cervix Classification Estrogen Estrogen receptors Estrogens Fallopian tubes Gynecology Human papillomavirus Informed consent Lymphatic system Magnetic resonance imaging Metastases Metastasis Obstetrics Ovarian cancer Papillomavirus infections Polymerase chain reaction Progesterone Surgery Tumors Uterus Vagina |
| title | A Rare Case of Primary Signet-Ring Cell Cervical Carcinoma: Early Stage with Independent Bilateral Ovarian Metastases |
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