PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiol...

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Veröffentlicht in:	European journal of immunology 2021-03, Vol.51 (3), p.734-737
Hauptverfasser:	Waard, Antonius A., Verkerk, Tamara, Jongsma, Marlieke L. M., Hoefakker, Kelly, Sethumadhavan, Sunesh, Gerke, Carolin, Bliss, Sophie, Kong, Xiangrui, Janssen, George M. C., Ru, Arnoud H., Claas, Frans H. J., Mulder, Arend, Tampé, Robert, Veelen, Peter A., Halenius, Anne, Spaapen, Robbert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen presentation Antigen Presentation - immunology APM Autoimmunity Autoimmunity - immunology Cell lines CRISPR/Cas9 Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology HLA class I Humans MHC Neoplasms - immunology Signal Transduction - immunology Technical Comment
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Beschreibung
Zusammenfassung:	A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA‐I research in the fields of oncology, infectiology, and autoimmunity.
ISSN:	0014-2980 1521-4141 1521-4141
DOI:	10.1002/eji.202048599