Difference in the efficacy of intravitreal dexamethasone implant before and after silicone oil removal: A case report
An intravitreal dexamethasone (IV-DEX) implant is safe and effective for the treatment of macular edemas; however, the efficacy of IV-DEX implants in silicone oil (SO)-filled eyes remains controversial. There is no previous study comparing an IV-DEX implant in the same eye with and without intravitr...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-03, Vol.100 (11), p.e25161-e25161 |
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| creator | An, Jae Hong Kim, Yu Cheol |
| description | An intravitreal dexamethasone (IV-DEX) implant is safe and effective for the treatment of macular edemas; however, the efficacy of IV-DEX implants in silicone oil (SO)-filled eyes remains controversial. There is no previous study comparing an IV-DEX implant in the same eye with and without intravitreal SO.
A 72-year-old man with proliferative diabetic retinopathy, macular edema, and rhegmatogenous retinal detachment, treated with pars plana vitrectomy with SO tamponade had refractory macular edema.
Refractory macular edema.
Subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation were performed; this was followed by intravitreal SO removal combined with IV-DEX implantation.
The macular edema did not decrease significantly with posterior subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation; however, the edema was relieved after SO removal and a new IV-DEX implantation.
IV-DEX implant may be less efficacious in the treatment of macular edema in an SO-filled eye than that in a normal vitreous cavity. |
| doi_str_mv | 10.1097/MD.0000000000025161 |
| format | Article |
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A 72-year-old man with proliferative diabetic retinopathy, macular edema, and rhegmatogenous retinal detachment, treated with pars plana vitrectomy with SO tamponade had refractory macular edema.
Refractory macular edema.
Subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation were performed; this was followed by intravitreal SO removal combined with IV-DEX implantation.
The macular edema did not decrease significantly with posterior subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation; however, the edema was relieved after SO removal and a new IV-DEX implantation.
IV-DEX implant may be less efficacious in the treatment of macular edema in an SO-filled eye than that in a normal vitreous cavity.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000025161</identifier><identifier>PMID: 33726001</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Aged ; Clinical Case Report ; Device Removal ; Dexamethasone - administration & dosage ; Diabetic Retinopathy - drug therapy ; Drug Implants - administration & dosage ; Humans ; Intravitreal Injections ; Macular Edema - drug therapy ; Male ; Retinal Detachment - drug therapy ; Silicone Oils - administration & dosage ; Triamcinolone - administration & dosage ; Vascular Endothelial Growth Factors - administration & dosage ; Vitrectomy - methods</subject><ispartof>Medicine (Baltimore), 2021-03, Vol.100 (11), p.e25161-e25161</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3552-1f4de562d2f29aca13fd31dbe7ed32e6478017c3e5690d5ac3d8bcece2da26403</cites><orcidid>0000-0003-1615-6651</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982211/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982211/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33726001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Jae Hong</creatorcontrib><creatorcontrib>Kim, Yu Cheol</creatorcontrib><title>Difference in the efficacy of intravitreal dexamethasone implant before and after silicone oil removal: A case report</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>An intravitreal dexamethasone (IV-DEX) implant is safe and effective for the treatment of macular edemas; however, the efficacy of IV-DEX implants in silicone oil (SO)-filled eyes remains controversial. There is no previous study comparing an IV-DEX implant in the same eye with and without intravitreal SO.
A 72-year-old man with proliferative diabetic retinopathy, macular edema, and rhegmatogenous retinal detachment, treated with pars plana vitrectomy with SO tamponade had refractory macular edema.
Refractory macular edema.
Subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation were performed; this was followed by intravitreal SO removal combined with IV-DEX implantation.
The macular edema did not decrease significantly with posterior subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation; however, the edema was relieved after SO removal and a new IV-DEX implantation.
IV-DEX implant may be less efficacious in the treatment of macular edema in an SO-filled eye than that in a normal vitreous cavity.</description><subject>Aged</subject><subject>Clinical Case Report</subject><subject>Device Removal</subject><subject>Dexamethasone - administration & dosage</subject><subject>Diabetic Retinopathy - drug therapy</subject><subject>Drug Implants - administration & dosage</subject><subject>Humans</subject><subject>Intravitreal Injections</subject><subject>Macular Edema - drug therapy</subject><subject>Male</subject><subject>Retinal Detachment - drug therapy</subject><subject>Silicone Oils - administration & dosage</subject><subject>Triamcinolone - administration & dosage</subject><subject>Vascular Endothelial Growth Factors - administration & dosage</subject><subject>Vitrectomy - methods</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi1ERZfCL0BCPnJJ8UcSxxyQqm75kFr1Us6W1x4TgxMvtrOl_x4vWwrUl9GMn3nH4xehV5ScUiLF26v1Kfl7WEd7-gStaMf7ppN9-xSt9tVGSNEeo-c5fyOEcsHaZ-iY19jXdIWWtXcOEswGsJ9xGQGDc95oc4ejq6WS9M6XBDpgCz_1BGXUOc6VnrZBzwVvwMUEWM8Wa1cg4eyDN3si-oATTHGnwzt8ho3OUPNtTOUFOnI6ZHh5H0_Qlw8XN-efmsvrj5_Pzy4bw7uONdS1FrqeWeaY1EZT7iyndgMCLGfQt2IgVBheGUlspw23w8aAAWY161vCT9D7g-522UxgDezXCWqb_KTTnYraq_9vZj-qr3GnhBwYo7QKvLkXSPHHArmoyWcDoW4OccmKdYQx0sphqCg_oCbFnBO4hzGUqL1h6mqtHhtWu17_-8KHnj8OVaA9ALcx1N_N38NyC0mN1ZAy_tbrhGQNI4wSTiVpamVg_BfkDaNr</recordid><startdate>20210319</startdate><enddate>20210319</enddate><creator>An, Jae Hong</creator><creator>Kim, Yu Cheol</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1615-6651</orcidid></search><sort><creationdate>20210319</creationdate><title>Difference in the efficacy of intravitreal dexamethasone implant before and after silicone oil removal: A case report</title><author>An, Jae Hong ; Kim, Yu Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3552-1f4de562d2f29aca13fd31dbe7ed32e6478017c3e5690d5ac3d8bcece2da26403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Clinical Case Report</topic><topic>Device Removal</topic><topic>Dexamethasone - administration & dosage</topic><topic>Diabetic Retinopathy - drug therapy</topic><topic>Drug Implants - administration & dosage</topic><topic>Humans</topic><topic>Intravitreal Injections</topic><topic>Macular Edema - drug therapy</topic><topic>Male</topic><topic>Retinal Detachment - drug therapy</topic><topic>Silicone Oils - administration & dosage</topic><topic>Triamcinolone - administration & dosage</topic><topic>Vascular Endothelial Growth Factors - administration & dosage</topic><topic>Vitrectomy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Jae Hong</creatorcontrib><creatorcontrib>Kim, Yu Cheol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Jae Hong</au><au>Kim, Yu Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Difference in the efficacy of intravitreal dexamethasone implant before and after silicone oil removal: A case report</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-03-19</date><risdate>2021</risdate><volume>100</volume><issue>11</issue><spage>e25161</spage><epage>e25161</epage><pages>e25161-e25161</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>An intravitreal dexamethasone (IV-DEX) implant is safe and effective for the treatment of macular edemas; however, the efficacy of IV-DEX implants in silicone oil (SO)-filled eyes remains controversial. There is no previous study comparing an IV-DEX implant in the same eye with and without intravitreal SO.
A 72-year-old man with proliferative diabetic retinopathy, macular edema, and rhegmatogenous retinal detachment, treated with pars plana vitrectomy with SO tamponade had refractory macular edema.
Refractory macular edema.
Subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation were performed; this was followed by intravitreal SO removal combined with IV-DEX implantation.
The macular edema did not decrease significantly with posterior subtenon triamcinolone injection, intravitreal anti-vascular endothelial growth factor injection, and IV-DEX implantation; however, the edema was relieved after SO removal and a new IV-DEX implantation.
IV-DEX implant may be less efficacious in the treatment of macular edema in an SO-filled eye than that in a normal vitreous cavity.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33726001</pmid><doi>10.1097/MD.0000000000025161</doi><orcidid>https://orcid.org/0000-0003-1615-6651</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Clinical Case Report Device Removal Dexamethasone - administration & dosage Diabetic Retinopathy - drug therapy Drug Implants - administration & dosage Humans Intravitreal Injections Macular Edema - drug therapy Male Retinal Detachment - drug therapy Silicone Oils - administration & dosage Triamcinolone - administration & dosage Vascular Endothelial Growth Factors - administration & dosage Vitrectomy - methods |
| title | Difference in the efficacy of intravitreal dexamethasone implant before and after silicone oil removal: A case report |
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