Assessment of the Circulating Tumor Cells and Microsatellite Instability in Colorectal Cancer Patients: Prognostic and Diagnostic Value

Assessment of the Circulating Tumor Cells and Microsatellite Instability in Colorectal Cancer Patients: Prognostic and Diagnostic Value

Microsatellite instability (MSI) and circulating tumor cells (CTCs) play important roles in the diagnosis, prognosis and management of colorectal cancer (CRC) patients. CTCs and MSI were assessed in the blood and representative tumor tissues of 100 CRC patients by flow cytometry (FCM) and PCR amplif...

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Veröffentlicht in:OncoTargets and therapy 2021-01, Vol.14, p.1937-1951
Hauptverfasser: Alsayed, Aya, Salem, Salem E, El Serafi, Mostafa M, Abdellateif, Mona S, Zekri, Abdel-Rahman N, Mohanad, Marwa, Bahnassy, Abeer A
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Cancer
Cancer therapies
Care and treatment
Cell division
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Flow cytometry
Genes
Genetic aspects
Lymph nodes
Metastases
Metastasis
Microsatellite instability
Multivariate analysis
Mutation
Original Research
Patients
Prognosis
Radiation therapy
Software
Surgery
Tumor cells
Tumors
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Zusammenfassung:Microsatellite instability (MSI) and circulating tumor cells (CTCs) play important roles in the diagnosis, prognosis and management of colorectal cancer (CRC) patients. CTCs and MSI were assessed in the blood and representative tumor tissues of 100 CRC patients by flow cytometry (FCM) and PCR amplification. The data were correlated to relevant clinicopathological features of the patients, progression-free survival (PFS) and overall survival (OS) rates. MSI-high was detected in 44 (44.0%) patients, MSI-low in 37 (37%), and microsatellite stable (MSS) in 19 (19.0%) patients (P=0.007). The baseline CTCs count (
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S292551