Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds

The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionoph...

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Veröffentlicht in:	RSC advances 2020-11, Vol.1 (66), p.4391-4394
Hauptverfasser:	Carrasquel-Ursulaez, Willy, Reeves, Ryan D, Dehghany, Mahzad, Jones, Corey, Schomaker, Jennifer M, Chanda, Baron
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Cytotoxicity Ethers Ion transport NMR Nuclear magnetic resonance Toxicity
Online-Zugang:	Volltext
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Zusammenfassung:	The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties. Herein, we provide evidence that these effects are due to loss of membrane integrity rather than ion transport, a finding with important implications for the future design of synthetic ionophores. The cytotoxicity of dialkylated lariat ethers has been previously attributed to their ionophoric properties.
ISSN:	2046-2069 2046-2069
DOI:	10.1039/d0ra08494h