Impact and Effectiveness of Monovalent Rotavirus Vaccine Against Severe Rotavirus Diarrhea in Ghana

Impact and Effectiveness of Monovalent Rotavirus Vaccine Against Severe Rotavirus Diarrhea in Ghana

Background. Ghana was among the first African nations to introduce monovalent rotavirus vaccine (RV1) into its childhood immunization schedule in April 2012. We aimed to assess the impact of vaccine introduction on rotavirus and acute gastroenteritis (AGE) hospitalizations and to estimate vaccine ef...

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Veröffentlicht in:Clinical infectious diseases 2016-05, Vol.62 (suppl 2), p.S200-S207
Hauptverfasser: Armah, George, Pringle, Kimberly, Enweronu-Laryea, Christabel C., Ansong, Daniel, Mwenda, Jason M., Diamenu, Stanley K., Narh, Clement, Lartey, Belinda, Binka, Fred, Grytdal, Scott, Patel, Manish, Parashar, Umesh, Lopman, Ben
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease - epidemiology
AFRICA
Child, Preschool
Children & youth
Diarrhea - epidemiology
Diarrhea - prevention & control
Diarrhea - virology
Epidemiological Monitoring
Female
Gastroenteritis - prevention & control
Gastroenteritis - virology
Ghana - epidemiology
Hospitalization
Humans
Immunization
Immunization Programs
Immunization Schedule
Infant
Logistic Models
Male
Regression analysis
Rotavirus
Rotavirus Infections - epidemiology
Rotavirus Infections - prevention & control
Rotavirus Infections - virology
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - immunology
Vaccination
Vaccine Potency
Vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Viruses
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Zusammenfassung:Background. Ghana was among the first African nations to introduce monovalent rotavirus vaccine (RV1) into its childhood immunization schedule in April 2012. We aimed to assess the impact of vaccine introduction on rotavirus and acute gastroenteritis (AGE) hospitalizations and to estimate vaccine effectiveness (VE). Methods. Using data from 2 teaching hospitals, monthly AGE and rotavirus admissions by age were examined 40 months before and 31 months after RV1 introduction using interrupted time-series analyses. From January 2013, we enrolled children
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciw014