Prognostic significance of serum inflammatory markers in esophageal cancer
Background The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC). Methods Consecutive 330 p...
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| Veröffentlicht in: | Esophagus : official journal of the Japan Esophageal Society 2021-04, Vol.18 (2), p.267-277 |
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| creator | Powell, Arfon G. M. T. Eley, Catherine Chin, Carven Coxon, Alexandra H Christian, Adam Lewis, Wyn G. |
| description | Background
The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC).
Methods
Consecutive 330 patients undergoing surgery for EC between 2004 and 2018 within a regional UK cancer network were identified. Serum measurements of haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), and differential neutrophil to lymphocyte ratio (NLR) were obtained before surgery, and correlated with histopathological factors and outcomes. Primary outcome measures were disease-free (DFS) and overall survival (OS).
Results
Of 330 OC patients, 294 underwent potentially curative esophagectomy. Univariable DFS analysis revealed pT, pN, pTNM stage (all
p
|
| doi_str_mv | 10.1007/s10388-020-00772-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7960607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2438993787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c525t-b1b74421a981dcf649503098922d9d4ff8709ebf2f7dc9687e9a303a4cf07ddc3</originalsourceid><addsrcrecordid>eNp9kU9P3DAQxa2KCrbbfoEeUKReuKQd20lsX5CqFZQiJDjA2fI6dtY0sRc7Qdpvj2GXLe2Bk__M772Z0UPoK4bvGID9SBgo5yUQKPOTkZJ-QDPcYFIKaNjB_l6LI_QppXsASipOD9ERJbypG0Jn6PImhs6HNDpdJNd5Z51WXpsi2CKZOA2F87ZXw6DGEDfFoOIfE1P-LEwK65XqjOqLF0X8jD5a1SfzZXfO0d352e3iory6_vV78fOq1DWpx3KJl6yqCFaC41bbphI1UBBcENKKtrKWMxBmaYllrRYNZ0YoClRV2gJrW03n6HTru56Wg2m18WNUvVxHl6fbyKCc_Lfi3Up24VEy0UADLBuc7AxieJhMGuXgkjZ9r7wJU5KkolwIyvgz-u0_9D5M0ef1JKkB05oDh0yRLaVjSCkaux8Gg3yOSm6jkjkq-RKVpFl0_HaNveQ1mwzQLZByyXcm_u39ju0THhegCA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501358080</pqid></control><display><type>article</type><title>Prognostic significance of serum inflammatory markers in esophageal cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Powell, Arfon G. M. T. ; Eley, Catherine ; Chin, Carven ; Coxon, Alexandra H ; Christian, Adam ; Lewis, Wyn G.</creator><creatorcontrib>Powell, Arfon G. M. T. ; Eley, Catherine ; Chin, Carven ; Coxon, Alexandra H ; Christian, Adam ; Lewis, Wyn G. ; South East Wales Oesophagogastric Cancer Collaborative</creatorcontrib><description><![CDATA[Background
The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC).
Methods
Consecutive 330 patients undergoing surgery for EC between 2004 and 2018 within a regional UK cancer network were identified. Serum measurements of haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), and differential neutrophil to lymphocyte ratio (NLR) were obtained before surgery, and correlated with histopathological factors and outcomes. Primary outcome measures were disease-free (DFS) and overall survival (OS).
Results
Of 330 OC patients, 294 underwent potentially curative esophagectomy. Univariable DFS analysis revealed pT, pN, pTNM stage (all
p
< 0.001), poor differentiation (
p
= 0.001), vascular invasion (
p
< 0.001), R1 status (
p
< 0.001), perioperative chemotherapy (
p
= 0.009), CRP (
p
= 0.010), mGPS (
p
= 0.011), and NLR (
p
< 0.001), were all associated with poor survival. Multivariable Cox regression analysis of DFS revealed only NLR [Hazard Ratio (HR) 3.63, 95% Confidence Interval (CI) 2.11–6.24,
p
< 0.001] retained significance. Multivariable Cox regression analysis of OS revealed similar findings: NLR [HR 2.66, (95% CI 1.58–4.50),
p
< 0.001].
Conclusion
NLR is an important SIR prognostic biomarker associated with DFS and OS in EC.]]></description><identifier>ISSN: 1612-9059</identifier><identifier>EISSN: 1612-9067</identifier><identifier>DOI: 10.1007/s10388-020-00772-3</identifier><identifier>PMID: 32865623</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adenocarcinoma ; Biomarkers ; Esophageal cancer ; Esophageal Neoplasms - drug therapy ; Esophagus ; Gastroenterology ; Humans ; Lymphocytes - pathology ; Medical prognosis ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Prognosis ; Regression analysis ; Surgery ; Surgical Oncology ; Thoracic Surgery</subject><ispartof>Esophagus : official journal of the Japan Esophageal Society, 2021-04, Vol.18 (2), p.267-277</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-b1b74421a981dcf649503098922d9d4ff8709ebf2f7dc9687e9a303a4cf07ddc3</citedby><cites>FETCH-LOGICAL-c525t-b1b74421a981dcf649503098922d9d4ff8709ebf2f7dc9687e9a303a4cf07ddc3</cites><orcidid>0000-0002-3740-8275</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10388-020-00772-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10388-020-00772-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32865623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Powell, Arfon G. M. T.</creatorcontrib><creatorcontrib>Eley, Catherine</creatorcontrib><creatorcontrib>Chin, Carven</creatorcontrib><creatorcontrib>Coxon, Alexandra H</creatorcontrib><creatorcontrib>Christian, Adam</creatorcontrib><creatorcontrib>Lewis, Wyn G.</creatorcontrib><creatorcontrib>South East Wales Oesophagogastric Cancer Collaborative</creatorcontrib><title>Prognostic significance of serum inflammatory markers in esophageal cancer</title><title>Esophagus : official journal of the Japan Esophageal Society</title><addtitle>Esophagus</addtitle><addtitle>Esophagus</addtitle><description><![CDATA[Background
The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC).
Methods
Consecutive 330 patients undergoing surgery for EC between 2004 and 2018 within a regional UK cancer network were identified. Serum measurements of haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), and differential neutrophil to lymphocyte ratio (NLR) were obtained before surgery, and correlated with histopathological factors and outcomes. Primary outcome measures were disease-free (DFS) and overall survival (OS).
Results
Of 330 OC patients, 294 underwent potentially curative esophagectomy. Univariable DFS analysis revealed pT, pN, pTNM stage (all
p
< 0.001), poor differentiation (
p
= 0.001), vascular invasion (
p
< 0.001), R1 status (
p
< 0.001), perioperative chemotherapy (
p
= 0.009), CRP (
p
= 0.010), mGPS (
p
= 0.011), and NLR (
p
< 0.001), were all associated with poor survival. Multivariable Cox regression analysis of DFS revealed only NLR [Hazard Ratio (HR) 3.63, 95% Confidence Interval (CI) 2.11–6.24,
p
< 0.001] retained significance. Multivariable Cox regression analysis of OS revealed similar findings: NLR [HR 2.66, (95% CI 1.58–4.50),
p
< 0.001].
Conclusion
NLR is an important SIR prognostic biomarker associated with DFS and OS in EC.]]></description><subject>Adenocarcinoma</subject><subject>Biomarkers</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophagus</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Lymphocytes - pathology</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Thoracic Surgery</subject><issn>1612-9059</issn><issn>1612-9067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9P3DAQxa2KCrbbfoEeUKReuKQd20lsX5CqFZQiJDjA2fI6dtY0sRc7Qdpvj2GXLe2Bk__M772Z0UPoK4bvGID9SBgo5yUQKPOTkZJ-QDPcYFIKaNjB_l6LI_QppXsASipOD9ERJbypG0Jn6PImhs6HNDpdJNd5Z51WXpsi2CKZOA2F87ZXw6DGEDfFoOIfE1P-LEwK65XqjOqLF0X8jD5a1SfzZXfO0d352e3iory6_vV78fOq1DWpx3KJl6yqCFaC41bbphI1UBBcENKKtrKWMxBmaYllrRYNZ0YoClRV2gJrW03n6HTru56Wg2m18WNUvVxHl6fbyKCc_Lfi3Up24VEy0UADLBuc7AxieJhMGuXgkjZ9r7wJU5KkolwIyvgz-u0_9D5M0ef1JKkB05oDh0yRLaVjSCkaux8Gg3yOSm6jkjkq-RKVpFl0_HaNveQ1mwzQLZByyXcm_u39ju0THhegCA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Powell, Arfon G. M. T.</creator><creator>Eley, Catherine</creator><creator>Chin, Carven</creator><creator>Coxon, Alexandra H</creator><creator>Christian, Adam</creator><creator>Lewis, Wyn G.</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3740-8275</orcidid></search><sort><creationdate>20210401</creationdate><title>Prognostic significance of serum inflammatory markers in esophageal cancer</title><author>Powell, Arfon G. M. T. ; Eley, Catherine ; Chin, Carven ; Coxon, Alexandra H ; Christian, Adam ; Lewis, Wyn G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-b1b74421a981dcf649503098922d9d4ff8709ebf2f7dc9687e9a303a4cf07ddc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenocarcinoma</topic><topic>Biomarkers</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - drug therapy</topic><topic>Esophagus</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Lymphocytes - pathology</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Thoracic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Powell, Arfon G. M. T.</creatorcontrib><creatorcontrib>Eley, Catherine</creatorcontrib><creatorcontrib>Chin, Carven</creatorcontrib><creatorcontrib>Coxon, Alexandra H</creatorcontrib><creatorcontrib>Christian, Adam</creatorcontrib><creatorcontrib>Lewis, Wyn G.</creatorcontrib><creatorcontrib>South East Wales Oesophagogastric Cancer Collaborative</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Esophagus : official journal of the Japan Esophageal Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Powell, Arfon G. M. T.</au><au>Eley, Catherine</au><au>Chin, Carven</au><au>Coxon, Alexandra H</au><au>Christian, Adam</au><au>Lewis, Wyn G.</au><aucorp>South East Wales Oesophagogastric Cancer Collaborative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of serum inflammatory markers in esophageal cancer</atitle><jtitle>Esophagus : official journal of the Japan Esophageal Society</jtitle><stitle>Esophagus</stitle><addtitle>Esophagus</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>18</volume><issue>2</issue><spage>267</spage><epage>277</epage><pages>267-277</pages><issn>1612-9059</issn><eissn>1612-9067</eissn><abstract><![CDATA[Background
The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC).
Methods
Consecutive 330 patients undergoing surgery for EC between 2004 and 2018 within a regional UK cancer network were identified. Serum measurements of haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), and differential neutrophil to lymphocyte ratio (NLR) were obtained before surgery, and correlated with histopathological factors and outcomes. Primary outcome measures were disease-free (DFS) and overall survival (OS).
Results
Of 330 OC patients, 294 underwent potentially curative esophagectomy. Univariable DFS analysis revealed pT, pN, pTNM stage (all
p
< 0.001), poor differentiation (
p
= 0.001), vascular invasion (
p
< 0.001), R1 status (
p
< 0.001), perioperative chemotherapy (
p
= 0.009), CRP (
p
= 0.010), mGPS (
p
= 0.011), and NLR (
p
< 0.001), were all associated with poor survival. Multivariable Cox regression analysis of DFS revealed only NLR [Hazard Ratio (HR) 3.63, 95% Confidence Interval (CI) 2.11–6.24,
p
< 0.001] retained significance. Multivariable Cox regression analysis of OS revealed similar findings: NLR [HR 2.66, (95% CI 1.58–4.50),
p
< 0.001].
Conclusion
NLR is an important SIR prognostic biomarker associated with DFS and OS in EC.]]></abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32865623</pmid><doi>10.1007/s10388-020-00772-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3740-8275</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1612-9059 |
| ispartof | Esophagus : official journal of the Japan Esophageal Society, 2021-04, Vol.18 (2), p.267-277 |
| issn | 1612-9059 1612-9067 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adenocarcinoma Biomarkers Esophageal cancer Esophageal Neoplasms - drug therapy Esophagus Gastroenterology Humans Lymphocytes - pathology Medical prognosis Medicine Medicine & Public Health Original Original Article Prognosis Regression analysis Surgery Surgical Oncology Thoracic Surgery |
| title | Prognostic significance of serum inflammatory markers in esophageal cancer |
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