Prognostic significance of serum inflammatory markers in esophageal cancer

Prognostic significance of serum inflammatory markers in esophageal cancer

Background The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC). Methods Consecutive 330 p...

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Veröffentlicht in:Esophagus : official journal of the Japan Esophageal Society 2021-04, Vol.18 (2), p.267-277
Hauptverfasser: Powell, Arfon G. M. T., Eley, Catherine, Chin, Carven, Coxon, Alexandra H, Christian, Adam, Lewis, Wyn G.
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
Biomarkers
Esophageal cancer
Esophageal Neoplasms - drug therapy
Esophagus
Gastroenterology
Humans
Lymphocytes - pathology
Medical prognosis
Medicine
Medicine & Public Health
Original
Original Article
Prognosis
Regression analysis
Surgery
Surgical Oncology
Thoracic Surgery
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Zusammenfassung:Background The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and potentially improve prognostic modeling in patients undergoing potentially curative surgery for esophageal adenocarcinoma (EC). Methods Consecutive 330 patients undergoing surgery for EC between 2004 and 2018 within a regional UK cancer network were identified. Serum measurements of haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), and differential neutrophil to lymphocyte ratio (NLR) were obtained before surgery, and correlated with histopathological factors and outcomes. Primary outcome measures were disease-free (DFS) and overall survival (OS). Results Of 330 OC patients, 294 underwent potentially curative esophagectomy. Univariable DFS analysis revealed pT, pN, pTNM stage (all p  
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-020-00772-3