Outcomes of Liver Transplantation Among Older Recipients With Nonalcoholic Steatohepatitis in a Large Multicenter US Cohort: the Re‐Evaluating Age Limits in Transplantation Consortium

The liver transplantation (LT) population is aging, with the need for transplant being driven by the growing prevalence of nonalcoholic steatohepatitis (NASH). Older LT recipients with NASH may be at an increased risk for adverse outcomes after LT. Our objective is to characterize outcomes in these...

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Veröffentlicht in:Liver transplantation 2020-11, Vol.26 (11), p.1492-1503
Hauptverfasser: Kwong, Allison J., Devuni, Deepika, Wang, Connie, Boike, Justin, Jo, Jennifer, VanWagner, Lisa, Serper, Marina, Jones, Lauren, Sharma, Rajani, Verna, Elizabeth C., Shor, Julia, German, Margarita N., Hristov, Alexander, Lee, Alexander, Spengler, Erin, Koteish, Ayman A., Sehmbey, Gurbir, Seetharam, Anil, John, Nimy, Patel, Yuval, Kappus, Matthew R., Couri, Thomas, Paul, Sonali, Salgia, Reena J., Nhu, Quan, Frenette, Catherine T., Lai, Jennifer C., Goel, Aparna
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Sprache:eng
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Zusammenfassung:The liver transplantation (LT) population is aging, with the need for transplant being driven by the growing prevalence of nonalcoholic steatohepatitis (NASH). Older LT recipients with NASH may be at an increased risk for adverse outcomes after LT. Our objective is to characterize outcomes in these recipients in a large multicenter cohort. All primary LT recipients ≥65 years from 2010 to 2016 at 13 centers in the Re‐Evaluating Age Limits in Transplantation (REALT) consortium were included. Of 1023 LT recipients, 226 (22.1%) were over 70 years old, and 207 (20.2%) had NASH. Compared with other LT recipients, NASH recipients were older (68.0 versus 67.3 years), more likely to be female (47.3% versus 32.8%), White (78.3% versus 68.0%), Hispanic (12.1% versus 9.2%), and had higher Model for End‐Stage Liver Disease–sodium (21 versus 18) at LT (P 
ISSN:1527-6465
1527-6473
DOI:10.1002/lt.25863