Functional connectome biotypes of chemotherapy-related cognitive impairment

Purpose Cancer-related cognitive impairment (CRCI) is a common neurotoxicity among patients with breast and other cancers. Neuroimaging studies have demonstrated measurable biomarkers of CRCI but have largely neglected the potential heterogeneity of the syndrome. Methods We used retrospective functional MRI data from 80 chemotherapy-treated breast cancer survivors to examine neurophysiologic subtypes or “biotypes” of CRCI. The breast cancer group consisted of training ( N = 57) and validation ( N = 23) samples. Results An unsupervised clustering approach using connectomes from the training sample identified three distinct biotypes. Cognitive performance ( p