Protein circuits reprogram cells

Protein circuits reprogram cells

Two protein circuit systems, split-protease-cleavable orthogonal coiled-coil logic (SPOC logic) and circuits of hacked orthogonal modular proteases (CHOMP), have been developed to permit rapid and logic function-based control of mammalian cellular signaling.

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Bibliographische Detailangaben
Veröffentlicht in:Nature chemical biology 2019-02, Vol.15 (2), p.96-97
Hauptverfasser: Wu, Yiqian, Wang, Yingxiao
Format: Artikel
Sprache:eng
Schlagworte:
631/80/86
631/92/468
631/92/469
631/92/552
Animals
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Boolean
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Circuits
Coils
Design
Engineering
Gene expression
Logic
News & Views
news-and-views
Proteins
Proteolysis
Signal Transduction
Synthetic biology
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Beschreibung
Zusammenfassung:Two protein circuit systems, split-protease-cleavable orthogonal coiled-coil logic (SPOC logic) and circuits of hacked orthogonal modular proteases (CHOMP), have been developed to permit rapid and logic function-based control of mammalian cellular signaling.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-018-0210-5