A randomised controlled 8-week crossover clinical evaluation of the 3M™ Coban™ 2 Layer Compression System versus Profore™ to evaluate the product performance in patients with venous leg ulcers

This study compared a two‐layer (Coban™ 2 Layer) and a four‐layer (Profore™) compression bandage system in venous leg ulcer patients. Participants (n = 81) were enrolled into an 8‐week, randomised, open‐label, ten‐centre, crossover clinical trial. The primary endpoint was bandage slippage measured at each dressing change. Secondary endpoints included wound healing, health‐related quality of life (HRQoL) and patient preference. Mean slippage estimated from a mixed analysis of variance model (697 visits) was 2·48 cm for the two‐layer system and 4·17 cm for the four‐layer system (P