Population‐based study to re‐evaluate optimal lymph node yield in colonic cancer

Background It is well established that lymph node (LN) yield in colonic cancer resection has prognostic significance, although optimal numbers are not clear. Here, LN thresholds associated with both LN positivity and survival were evaluated in a single population‐based data set. Methods Treatment re...

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Veröffentlicht in:	British journal of surgery 2017-07, Vol.104 (8), p.1087-1096
Hauptverfasser:	Del Paggio, J. C., Peng, Y., Wei, X., Nanji, S., MacDonald, P. H., Krishnan Nair, C., Booth, C. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Distribution Aged Aged, 80 and over Cancer Colonic Neoplasms - mortality Colonic Neoplasms - surgery Colorectal cancer Epidemiologic Methods Female Health risk assessment Humans Lymph Node Excision - mortality Lymphatic Metastasis Lymphatic system Male Middle Aged Ontario - epidemiology Original Population-based studies Socioeconomic Factors Young Adult
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Zusammenfassung:	Background It is well established that lymph node (LN) yield in colonic cancer resection has prognostic significance, although optimal numbers are not clear. Here, LN thresholds associated with both LN positivity and survival were evaluated in a single population‐based data set. Methods Treatment records were linked to the Ontario Cancer Registry to identify a 25 per cent random sample of all patients with stage II/III colonic cancer between 2002 and 2008. Multivariable regression and Cox models evaluated factors associated with LN positivity and cancer‐specific survival (CSS) respectively. Optimal thresholds were obtained using sequential regression analysis. Results On adjusted analysis of 5508 eligible patients, younger age (P
ISSN:	0007-1323 1365-2168
DOI:	10.1002/bjs.10540