Utilizing left atrial strain to identify patients at risk for atrial fibrillation on ibrutinib

Background Ibrutinib is associated with atrial fibrillation (AF), though echocardiographic predictors of AF have not been studied in this population. We sought to determine whether left atrial (LA) strain on transthoracic echocardiography could identify patients at risk for developing ibrutinib‐related atrial fibrillation (IRAF). Methods We performed a retrospective review of 66 patients who had an echocardiogram prior to ibrutinib treatment. LA strain was measured with TOMTEC Imaging Systems, obtaining peak atrial longitudinal strain (PALS) and peak atrial contraction strain (PACS) on 4‐chamber and 2‐chamber views. Statistical analysis was performed with chi‐square analysis, t test, or binomial regression analysis, with a P‐value