Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT

Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT

The nucleophosmin 1 (NPM1) protein is frequently overexpressed in various cancers compared to normal tissues and represents a potential biomarker for maliganancy. However, its role in colorectal cancer (CRC) is still not fully understood. In this report, we show that NPM1 levels in CRC correlate wit...

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Veröffentlicht in:Cancer biology & therapy 2021-02, Vol.22 (2), p.112-123
Hauptverfasser: Yu, Angel C.Y., Chern, Yi-Jye, Zhang, Peter, Pasiliao, Clarissa C., Rahman, Mahbuba, Chang, George, Ren, Jianhua, Tai, Isabella T.
Format: Artikel
Sprache:eng
Schlagworte:
AKT
Animals
apoptosis
chemoresistance
colorectal cancer
Colorectal Neoplasms - drug therapy
Humans
Mice
Nucleophosmin
Nucleophosmin - antagonists & inhibitors
Proto-Oncogene Proteins c-akt - metabolism
Research Paper
Signal Transduction
Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:The nucleophosmin 1 (NPM1) protein is frequently overexpressed in various cancers compared to normal tissues and represents a potential biomarker for maliganancy. However, its role in colorectal cancer (CRC) is still not fully understood. In this report, we show that NPM1 levels in CRC correlate with prognosis and sensitivity to chemotherapy. NPM1 expression was found to be significantly increased in CRC tumors (P
ISSN:1538-4047
1555-8576
DOI:10.1080/15384047.2020.1839278